Showing 1 to 14 of 14 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000271 2 all-match P2Y purinoceptor 1 NAs.000271 EC50 > 100000.0 nM Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes CHEMBL1135773
NAs.000271 2 all-match Purinergic receptor P2Y12 NAs.000271 EC50 > 100000.0 nM Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) CHEMBL1135773
NAs.000271 2 all-match P2X purinoceptor 1 NAs.000271 EC50 = 2000.0 nM Antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 ) CHEMBL1135773
NAs.000271 2 all-match P2X purinoceptor 3 NAs.000271 EC50 = 9200.0 nM The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 3 uM, expressed in Xenopus oocytes CHEMBL1135773
NAs.000271 2 all-match P2Y purinoceptor 1 NAs.000271 Other None None None Agonist activity by measuring Purinoceptor P2Y1-promoted phospholipase C activity in turkey erythrocyte membranes; No effect as either agonist or antagonist at 10 uM CHEMBL1135410
NAs.000271 2 all-match Purinergic receptor P2Y1 NAs.000271 Other None None None Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 1; No effect as either agonist or antagonist at 10 uM CHEMBL1135410
NAs.000271 2 all-match Purinergic receptor P2Y2 NAs.000271 Other None None None Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 2; No effect as either agonist or antagonist at 10 uM CHEMBL1135410
NAs.000271 2 all-match S-adenosylmethionine synthetase gamma form NAs.000271 Ki None None nM Inhibitory constant against rat kidney Methionine adenosyltransferase II; Not determined CHEMBL1123521
NAs.000271 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.000271 Ki None None nM Inhibitory constant against rat Methionine adenosyltransferase was reported; Not determined CHEMBL1123521
NAs.000271 2 all-match Glycerol kinase NAs.000271 Ki = 300000.0 nM Tested for its binding affinity against glycerol kinase (ATP competitive inhibition) CHEMBL1130575
NAs.000271 2 all-match No relevant target NAs.000271 Other = 8.4 None pKa value was evaluated CHEMBL1130575
NAs.000271 2 all-match Aldehyde dehydrogenase 1A1 NAs.000271 Other = 39810.7 nM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] CHEMBL1201862
NAs.000271 2 all-match No relevant target NAs.000271 Other = 8.4 None Conversion of compound to its pyrophosphate assessed as acid dissociation constant (second deprotonation) CHEMBL3217618
NAs.004611 6 all-match Human immunodeficiency virus type 1 reverse transcriptase NAs.004611 IC50 = 6950.0 nM Compound concentration that causes 50 % inhibition of HIV-1 peptide-derived reverse transcriptase (RT) CHEMBL1125995