Showing 1 to 7 of 7 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000655 4 all-match SARS-CoV-2 NAs.000655 Other = -9.07 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging CHEMBL4303101
NAs.000655 4 all-match NAD(+) hydrolase SARM1 NAs.000655 Other None None None Substrate activity at StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells assessed as increase in in NADase activity in presence of NAD+ incubated for 60 mins by HPLC analysis CHEMBL4421736
NAs.000655 4 all-match NAD(+) hydrolase SARM1 NAs.000655 Other None None None Substrate activity at StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells assessed as increase in in NADase activity at 100 uM in presence of NAD+ incubated for 60 mins by HPLC analysis CHEMBL4421736
NAs.000655 4 all-match Replicase polyprotein 1ab NAs.000655 Other = 6.992999999999999 % SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate CHEMBL4495564
NAs.000655 4 all-match SARS-CoV-2 NAs.000655 Other = -0.05 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging CHEMBL4495565
NAs.000655 4 all-match SARS-CoV-2 NAs.000655 Other = -0.05 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging CHEMBL4495565
NAs.000655 4 all-match Unchecked NAs.000655 Other = 3.0 degrees C Binding affinity to Pseudomonas aeruginosa MurB assessed as change in melting temperature at 1 mM by differential scanning fluorimetry CHEMBL5038657