| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000818 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 1 |  |
Ki | = | 300.0 | nM | Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I) | CHEMBL1135710 | |
| NAs.000818 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
Ki | = | 300.0 | nM | Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) | CHEMBL1135710 | |
| NAs.000818 | 4 | all-match | K562 | |
IC50 | = | 11000.0 | nM | Concentration of the Antiproliferative compound required for the 50% inhibition of Growth against K562 cells | CHEMBL1135710 | |
| NAs.000818 | 4 | all-match | K562 | |
Other | = | 48.0 | % | Compound effect on differentiation of K562 cells, % of benzidine positive cells at 14 uM | CHEMBL1135710 | |
| NAs.000818 | 4 | all-match | K562 | |
Other | = | 3.4 | % | Compound effect on differentiation of K562 cells, % of benzidine positive cells at 1.0 uM | CHEMBL1135710 | |
| NAs.000818 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
Other | = | 0.17 | uM | Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from intercept of Michaelis-Menten plot | CHEMBL1128279 | |
| NAs.000818 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
Other | = | 0.3 | uM | Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from slope of Michaelis-Menten plot | CHEMBL1128279 | |
| NAs.000818 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
IC50 | = | 300.0 | nM | The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 | CHEMBL1130108 | |
| NAs.000818 | 4 | all-match | K562 | |
IC50 | = | 11000.0 | nM | Antiproliferative activity against K562 erythroid leukemic cells was determined. | CHEMBL1130108 | |
| NAs.000818 | 4 | all-match | K562 | |
Other | = | 14.0 | uM | The concentration used to induce differentiation in K562 cells | CHEMBL1130108 | |
| NAs.000818 | 4 | all-match | K562 | |
Other | = | 48.0 | % | The ability to induce differentiation in K562 cells was estimated by determining the fraction of benzidine positive cells converted following incubation with the compound. | CHEMBL1130108 | |
| NAs.000818 | 4 | all-match | Unchecked | |
Other | = | 3.4 | % | Percentage of benzidine positive cells is divided by the concentration used. | CHEMBL1130108 | |