Showing 1 to 50 of 77 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000956 2 all-match S-adenosylmethionine synthetase gamma form NAs.000956 Ki = 5500.0 nM Inhibitory constant against rat kidney Methionine adenosyltransferase II CHEMBL1123521
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.37 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as SIIHRDLK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 1.03 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as SNNIFLHEDLTVK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.79 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as IGDFGLATVK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.62 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as DQIIFMVGR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.82 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as GYLSPDLSK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.95 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as SASEPSLNR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 1.14 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as TPIQAGGYGAFPVH accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Centromere-associated protein E NAs.000956 Other > 30.0 % Inhibition of porcine brain microtubule-stimulated human recombinant GST-tagged CENP-E ATPase activity at 1 mM by microplate reader in presence of Mg2+ ATP relative to control CHEMBL3751740
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.72 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as QTAQGMDYLHAK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Chromosome-associated kinesin KIF4A NAs.000956 Other > 30.0 % Inhibition of porcine brain microtubule-stimulated human recombinant GST-tagged Kif4A ATPase activity at 1 mM by microplate reader in presence of Mg2+ ATP relative to control CHEMBL3751740
NAs.000956 2 all-match Kinesin-1 heavy chain NAs.000956 Other > 30.0 % Inhibition of porcine brain microtubule-stimulated human recombinant GST-tagged Kif5B ATPase activity at 1 mM by microplate reader in presence of Mg2+ ATP relative to control CHEMBL3751740
NAs.000956 2 all-match Kinesin-like protein KIF3C NAs.000956 Other > 30.0 % Inhibition of porcine brain microtubule-stimulated human recombinant GST-tagged KIF3C ATPase activity at 1 mM by microplate reader in presence of Mg2+ ATP relative to control CHEMBL3751740
NAs.000956 2 all-match Kinesin-like protein KIFC3 NAs.000956 Other > 30.0 % Inhibition of porcine brain microtubule-stimulated human recombinant GST-tagged KIFC3 ATPase activity at 1 mM by microplate reader in presence of Mg2+ ATP relative to control CHEMBL3751740
NAs.000956 2 all-match Kinesin-like protein KIF23 NAs.000956 Other > 30.0 % Inhibition of porcine brain microtubule-stimulated human recombinant GST-tagged MKLP1 ATPase activity at 1 mM by microplate reader in presence of Mg2+ ATP relative to control CHEMBL3751740
NAs.000956 2 all-match Heat shock protein HSP 90-alpha NAs.000956 Other None None None Binding affinity to 1H/13C-Ile HSP90alpha CTD (unknown origin) at 2.5 mM by Methyl-TROSY 15N HSQC spectrum analysis CHEMBL4257528
NAs.000956 2 all-match Sensor protein kinase WalK NAs.000956 IC50 = 228000.0 nM Inhibition of Streptococcus pneumoniae VicK autophosphorylation using compound at non-aggregating concentration after 30 mins in presence of [gamma-33P]-ATP by phosphorescence-based assay CHEMBL4270516
NAs.000956 2 all-match Casein kinase II alpha NAs.000956 Other None None None Binding affinity to CK2alpha (unknown origin) at 500 uM by STD-based NMR spectroscopy CHEMBL4411337
NAs.000956 2 all-match Unchecked NAs.000956 Other None None % Inhibition of recombinant human RAD51/p53 (unknown origin) interaction at 200 uM measured by ELISA assay CHEMBL5113497
NAs.000956 2 all-match Kinesin-like protein 1 NAs.000956 Other > 30.0 % Inhibition of porcine brain microtubule-stimulated human recombinant GST-tagged Eg5 ATPase activity at 1 mM by microplate reader in presence of Mg2+ ATP relative to control CHEMBL3751740
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.55 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as LIDIAR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Unchecked NAs.000956 IC50 = 48170.0 nM Inhibition of Thermotoga maritima HK853 autophosphorylation using compound at non-aggregating concentration after 30 mins in presence of [gamma-33P]-ATP by phosphorescence-based assay CHEMBL4270516
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.67 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as WHGDVAVK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.000956 Ki = 4000.0 nM Inhibitory constant against rat Methionine adenosyltransferase was reported CHEMBL1123521
NAs.000956 2 all-match S-adenosylmethionine synthetase gamma form NAs.000956 Other = 25.5 None Inhibitory potency against rat Methionine adenosyltransferase II CHEMBL1123521
NAs.000956 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.000956 Other = 35.0 None Inhibitory potency against rat Methionine adenosyltransferase was reported CHEMBL1123521
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.46 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as NEVGVLR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.000956 Other = 1.4 None Relative inhibitory potency T/II in rat methionine adenosyltransferase CHEMBL1123521
NAs.000956 2 all-match Glycerol kinase NAs.000956 Ki = 900000.0 nM Tested for its binding affinity against glycerol kinase (ATP competitive inhibition) CHEMBL1130575
NAs.000956 2 all-match No relevant target NAs.000956 Other = 7.7 None pKa value was evaluated CHEMBL1130575
NAs.000956 2 all-match Unchecked NAs.000956 Ki = 14200.0 nM Inhibition of APH(3')-3a by PK/LDH-coupled assay CHEMBL1255466
NAs.000956 2 all-match Unchecked NAs.000956 Ki = 263000.0 nM Inhibition of aminoglycoside 3'-phosphotransferase 1B by PK/LDH-coupled assay CHEMBL1255466
NAs.000956 2 all-match Unchecked NAs.000956 Ki None None None Inhibition of macrolide 2'-phosphotransferase 1 by PK/LDH-coupled assay CHEMBL1255466
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.83 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as SPQKPIVR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.91 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as VFLPNK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.89 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as 7VVPAR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.76 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as DSLKK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 1.0 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as SIPIPQPFRPADEDHR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.98 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as GDGGSTTGLSATPPASLPGSLTNVK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.71 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as DSSDDWEIPDGQITVGQR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match Serine/threonine-protein kinase B-raf NAs.000956 Other = 0.83 None Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as IGSGSFGTVYK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control CHEMBL3414549
NAs.000956 2 all-match No relevant target NAs.000956 Other = 7.7 None Conversion of compound to its pyrophosphate assessed as acid dissociation constant (second deprotonation) CHEMBL3217618
NAs.001630 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.001630 Ki = 2700.0 nM Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when Methionine was the variable substrate CHEMBL1124617
NAs.001630 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.001630 Ki = 270.0 nM Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when ATP was the variable substrate CHEMBL1124617
NAs.001630 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.001630 Ki = 5400.0 nM Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when Methionine was the variable substrate CHEMBL1124617
NAs.001630 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.001630 Ki = 410.0 nM Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when ATP was the variable substrate CHEMBL1124617
NAs.002242 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.002242 Ki = 630.0 nM Inhibition constant of ATP varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells CHEMBL1124309
NAs.002242 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.002242 Ki = 2700.0 nM Inhibition constant of Met varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells CHEMBL1124309
NAs.002242 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.002242 Ki = 390.0 nM Inhibition constant of ATP varied compound was measured on M-2 variate methionine adenosyltransferase in rat kidney CHEMBL1124309
NAs.002242 2 all-match S-adenosylmethionine synthetase (MAT 1 and MAT 2) NAs.002242 Ki = 2200.0 nM Inhibition constant of Met varied compound was measured on M-2 variant methionine adenosyltransferase in rat kidney CHEMBL1124309