Showing 1 to 40 of 40 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.001271 2 all-match Choline acetylase NAs.001271 Ki None None nM Compound was tested for inhibition of choline acetyltransferase isolated from squid head ganglia; No inhibition at 10e-4 M CHEMBL1121773
NAs.001271 2 all-match Squalene synthetase NAs.001271 Other = 3800.0 nmol/min/mg Activity of human full length squalene synthase expressed in baculovirus CHEMBL1145517
NAs.001271 2 all-match Unchecked NAs.001271 Other = 530000.0 nM Activity of Saccharomyces cerevisiae C-terminal truncated squalene synthase CHEMBL1145517
NAs.001271 2 all-match Unchecked NAs.001271 Other = 23340.0 nM Activity of Trypanosoma cruzi truncated squalene synthase 24/36 CHEMBL1145517
NAs.001271 2 all-match Unchecked NAs.001271 Other = 1853.24 nmol/min/mg Activity of Trypanosoma cruzi truncated squalene synthase 24/36 CHEMBL1145517
NAs.001271 2 all-match Unchecked NAs.001271 Other = 38880.0 nM Activity of Streptococcus pneumoniae recombinant HMGR class II expressed in Escherichia coli BL21(DE3) using NADPH as substrate after 5 min by microplate reader CHEMBL1817576
NAs.001271 2 all-match Unchecked NAs.001271 Other = 11.95 /s Activity of Streptococcus pneumoniae recombinant HMGR class II expressed in Escherichia coli BL21(DE3) using NADPH as substrate after 5 min by microplate reader CHEMBL1817576
NAs.001271 2 all-match Unchecked NAs.001271 Other = 12900.0 nM Activity of Listeria monocytogenes HMGR class II expressed in Escherichia coli BL21(DE3) using NADPH as substrate after 5 min by microplate reader CHEMBL1817576
NAs.001271 2 all-match Squalene synthetase NAs.001271 Other = 430000.0 nM Activity of human full length squalene synthase expressed in baculovirus CHEMBL1145517
NAs.001271 2 all-match Unchecked NAs.001271 Other = 22.6 /s Activity of Listeria monocytogenes HMGR class II expressed in Escherichia coli BL21(DE3) using NADPH as substrate after 5 min by microplate reader CHEMBL1817576
NAs.001271 2 all-match Unchecked NAs.001271 Other = 66000.0 nM Activity of Haloferax volcanii HMGR class I expressed in Escherichia coli BL21(DE3) using NADPH as substrate after 5 min by microplate reader CHEMBL1817576
NAs.001271 2 all-match Unchecked NAs.001271 Other = 80000.0 nM Activity of syrian hamsters HMGR class I expressed in Escherichia coli BL21(DE3) using NADPH as substrate after 5 min by microplate reader CHEMBL1817576
NAs.001271 2 all-match Unchecked NAs.001271 Other = 322.35 /s/M Ratio of Kcat to Km for Streptococcus pneumoniae HMGR class II using NADPH substrate CHEMBL1817576
NAs.001271 2 all-match Unchecked NAs.001271 Other = 185.71 /s/M Ratio of Kcat to Km for Listeria monocytogenes HMGR class II using NADPH substrate CHEMBL1817576
NAs.001271 2 all-match Solute carrier organic anion transporter family member 1B3 NAs.001271 Other = 105.1 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM CHEMBL3039007
NAs.001271 2 all-match Solute carrier organic anion transporter family member 1B1 NAs.001271 Other = 190.03 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM CHEMBL3039007
NAs.001271 2 all-match Replicase polyprotein 1ab NAs.001271 Other = 16.44 % SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate CHEMBL4495564
NAs.001271 2 all-match Unchecked NAs.001271 Other = 70000.0 nM Activity of Staphylococcus aureus HMGR class II expressed in Escherichia coli BL21(DE3) using NADPH as substrate after 5 min by microplate reader CHEMBL1817576
NAs.001271 2 all-match Unchecked NAs.001271 Other = 0.84 nmol/min/mg Activity of Leishmania mexicana microsomal or mitochondrial squalene synthase CHEMBL1145517
NAs.001271 2 all-match Unchecked NAs.001271 Other = 57000.0 nM Activity of Leishmania mexicana microsomal or mitochondrial squalene synthase CHEMBL1145517
NAs.001271 2 all-match Unchecked NAs.001271 Other = 0.58 nmol/min/mg Activity of Leishmania mexicana glycosomal squalene synthase CHEMBL1145517
NAs.001271 2 all-match Homo sapiens NAs.001271 Other = 40.0 None Dissociation constant towards human wild type DHFR CHEMBL1129559
NAs.001271 2 all-match Mus musculus NAs.001271 Other = 1.85 None Dissociation constant towards mouse wild type DHFR CHEMBL1129559
NAs.001271 2 all-match Unchecked NAs.001271 Other = 0.05 None Dissociation constant towards wild type DHFR CHEMBL1129559
NAs.001271 2 all-match Homo sapiens NAs.001271 Other = 25.0 None Dissociation constant towards human DHFR mutant hF31S CHEMBL1129559
NAs.001271 2 all-match Unchecked NAs.001271 Other = None None Dissociation constant towards DHFR mutant hF31S; no data CHEMBL1129559
NAs.001271 2 all-match Mus musculus NAs.001271 Other = 1.4 None Dissociation constant towards mouse DHFR mutant hF31S CHEMBL1129559
NAs.001271 2 all-match Homo sapiens NAs.001271 Other = 0.6 None Dissociation constant towards DHFR mutant F31W CHEMBL1129559
NAs.001271 2 all-match Dihydrofolate reductase NAs.001271 Other = 3.5 s-1 Dissociation rate constant of compound for wild type Escherichia coli dihydrofolate reductase CHEMBL1125508
NAs.001271 2 all-match Dihydrofolate reductase NAs.001271 Other = 60.0 s-1 Dissociation rate constant of compound for mutant T46S Escherichia coli dihydrofolate reductase CHEMBL1125508
NAs.001271 2 all-match Dihydrofolate reductase NAs.001271 Other = 56.0 s-1 Dissociation rate constant of compound for mutant T46N Escherichia coli dihydrofolate reductase CHEMBL1125508
NAs.001271 2 all-match Dihydrofolate reductase NAs.001271 Other = 28.0 s-1 Dissociation rate constant of compound for mutant T46A Escherichia coli dihydrofolate reductase CHEMBL1125508
NAs.001271 2 all-match Ketopantoate reductase NAs.001271 Other = 260.0 nM Binding affinity to Escherichia coli KPR CHEMBL1145346
NAs.001271 2 all-match Unchecked NAs.001271 Other = 40000.0 nM Activity of Trypanosoma cruzi glycosomal squalene synthase CHEMBL1145517
NAs.001271 2 all-match Unchecked NAs.001271 Other = 0.43 nmol/min/mg Activity of Trypanosoma cruzi glycosomal squalene synthase CHEMBL1145517
NAs.001271 2 all-match Unchecked NAs.001271 Other = 33000.0 nM Activity of Trypanosoma cruzi microsomal or mitochondrial squalene synthase CHEMBL1145517
NAs.001271 2 all-match Unchecked NAs.001271 Other = 0.76 nmol/min/mg Activity of Trypanosoma cruzi microsomal or mitochondrial squalene synthase CHEMBL1145517
NAs.001271 2 all-match Unchecked NAs.001271 Other = 62000.0 nM Activity of Leishmania mexicana glycosomal squalene synthase CHEMBL1145517
NAs.001271 2 all-match SARS-CoV-2 NAs.001271 Other = -0.03 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging CHEMBL4495565
NAs.001271 2 all-match SARS-CoV-2 NAs.001271 Other = -0.03 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging CHEMBL4495565