| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.001640 | 2 | all-match | Human immunodeficiency virus type 1 reverse transcriptase |  |
Ki | = | 320.0 | nM | Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt) | CHEMBL1145749 | |
| NAs.001640 | 2 | all-match | Human immunodeficiency virus type 1 reverse transcriptase | |
Ki | = | 1700.0 | nM | Inhibitory activity against HIV-1 reverse transcriptase (RT M184V) | CHEMBL1145749 | |
| NAs.001640 | 2 | all-match | Human immunodeficiency virus type 1 reverse transcriptase | |
Ki | = | 2400.0 | nM | Inhibitory activity against HIV-1 reverse transcriptase (RT M184I) | CHEMBL1145749 | |
| NAs.001640 | 2 | all-match | Unchecked | |
Other | = | 0.8 | None | Ratio of inhibitory activity of compound to that of substrate activity of dATP against RT wt enzyme was determined | CHEMBL1145749 | |
| NAs.001640 | 2 | all-match | Unchecked | |
Other | = | 4.5 | None | Ratio of inhibitory activity of compound to that of substrate activity of dATP against RT M184V enzyme was determined | CHEMBL1145749 | |
| NAs.001640 | 2 | all-match | Unchecked | |
Other | = | 6.3 | None | Ratio of inhibitory activity of compound to that of substrate activity of dATP against RT M184I enzyme was determined | CHEMBL1145749 | |
| NAs.002947 | 2 | all-match | Human immunodeficiency virus type 1 reverse transcriptase |  |
Ki | = | 10000.0 | nM | Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt) | CHEMBL1145749 | |
| NAs.002947 | 2 | all-match | Human immunodeficiency virus type 1 reverse transcriptase | |
Ki | = | 52000.0 | nM | Inhibitory activity against HIV-1 reverse transcriptase (RT M184V) | CHEMBL1145749 | |
| NAs.002947 | 2 | all-match | Human immunodeficiency virus type 1 reverse transcriptase | |
Ki | = | 71000.0 | nM | Inhibitory activity against HIV-1 reverse transcriptase (RT M184I) | CHEMBL1145749 | |
| NAs.002947 | 2 | all-match | Unchecked | |
Other | = | 25.0 | None | Ratio of inhibitory activity of compound to that of substrate activity of dATP against RT wt enzyme was determined | CHEMBL1145749 | |
| NAs.002947 | 2 | all-match | Unchecked | |
Other | = | 137.0 | None | Ratio of inhibitory activity of compound to that of substrate activity of dATP against RT M184V enzyme was determined | CHEMBL1145749 | |
| NAs.002947 | 2 | all-match | Unchecked | |
Other | = | 187.0 | None | Ratio of inhibitory activity of compound to that of substrate activity of dATP against RT M184I enzyme was determined | CHEMBL1145749 | |
| NAs.004647 | 6 | all-match | Human immunodeficiency virus type 1 reverse transcriptase |  |
IC50 | = | 34.0 | nM | Inhibitory effect on HIV-1 reverse transcriptase activity using poly(rA)-oligo(dT) template primer | CHEMBL1124679 | |
| NAs.004647 | 6 | all-match | Human immunodeficiency virus type 1 reverse transcriptase | |
IC50 | None | None | nM | Inhibitory effect on HIV-1 reverse transcriptase activity using poly(rC)-oligo(dG) template primer; ND is Not Determined | CHEMBL1124679 | |
| NAs.005111 | 7 | all-match | Human immunodeficiency virus type 1 reverse transcriptase |  |
IC50 | = | 280000.0 | nM | Inhibitory effect on HIV-1 reverse transcriptase activity using poly(rA)-oligo(dT) template primer | CHEMBL1124679 | |
| NAs.005111 | 7 | all-match | Human immunodeficiency virus type 1 reverse transcriptase | |
IC50 | = | 500000.0 | nM | Inhibitory effect on HIV-1 reverse transcriptase activity using poly(rC)-oligo(dG) template primer | CHEMBL1124679 | |