Showing 1 to 16 of 16 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.001928 2 all-match Mus musculus NAs.001928 Other None None None Cardiovascular toxicity in A1AR knock out C57BL/6 mouse assessed as change in body temperature at 5000 nmol/kg, po CHEMBL2163273
NAs.001928 2 all-match Mus musculus NAs.001928 Other None None None Cardiovascular toxicity in A1AR knock out C57BL/6 mouse assessed as change in heart rate at 5000 nmol/kg, po CHEMBL2163273
NAs.001928 2 all-match Mus musculus NAs.001928 Other None None None Cardiovascular toxicity in C57BL/6 mouse assessed as change in body temperature at 5000 nmol/kg, po CHEMBL2163273
NAs.001928 2 all-match Mus musculus NAs.001928 Other None None None Cardiovascular toxicity in C57BL/6 mouse assessed as change in heart rate at 5000 nmol/kg, po CHEMBL2163273
NAs.001928 2 all-match Mus musculus NAs.001928 Other None None None Antinociceptive effect in A1AR knock out C57BL/6 mouse assessed as inhibition of noxious thermal sensitivity by measuring paw withdrawal latency at 5 nmol/kg, it CHEMBL2163273
NAs.001928 2 all-match Mus musculus NAs.001928 Other None None None Antinociceptive effect in intravenously dosed C57BL/6 mouse assessed as inhibition of noxious thermal sensitivity by measuring paw withdrawal latency CHEMBL2163273
NAs.001928 2 all-match Mus musculus NAs.001928 Other None None None Antinociceptive effect in intrathecally dosed C57BL/6 mouse assessed as inhibition of noxious thermal sensitivity by measuring paw withdrawal latency CHEMBL2163273
NAs.001928 2 all-match Mus musculus NAs.001928 Other None None None Antinociceptive effect in orally dosed C57BL/6 mouse assessed as inhibition of noxious thermal sensitivity by measuring paw withdrawal latency CHEMBL2163273
NAs.001928 2 all-match Adenosine A3 receptor NAs.001928 Ki = 450.0 nM Displacement of [3H]2-chloro-N6-cyclopentyladenosine from human A3AR CHEMBL2163273
NAs.001928 2 all-match Adenosine A2a receptor NAs.001928 Ki = 4700.0 nM Displacement of [3H]2-chloro-N6-cyclopentyladenosine from human A2AR CHEMBL2163273
NAs.001928 2 all-match Adenosine A2b receptor NAs.001928 Other = 7.0 % Displacement of [3H]2-chloro-N6-cyclopentyladenosine from human A2BR at 50 uM CHEMBL2163273
NAs.001928 2 all-match Unchecked NAs.001928 Other = 12.0 None Selectivity ratio of Ki for human A3AR to Ki for human A1AR CHEMBL2163273
NAs.001928 2 all-match Unchecked NAs.001928 Other = 130.0 None Selectivity ratio of Ki for human A2AR to Ki for human A1AR CHEMBL2163273
NAs.001928 2 all-match Adenosine A1 receptor NAs.001928 Ki = 36.0 nM Displacement of [3H]2-chloro-N6-cyclopentyladenosine from human A1AR CHEMBL2163273
NAs.001928 2 all-match Adenosine A1 receptor NAs.001928 EC50 = 520.0 nM Agonist activity at human A1AR assessed as induction of Ca2+ ion mobilization by orthogonal functional assay CHEMBL2163273
NAs.001928 2 all-match Adenosine A1 receptor NAs.001928 EC50 = 1400.0 nM Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay CHEMBL2163273