| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.002232 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 |  |
IC50 | = | 800.0 | nM | The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 | CHEMBL1130108 | |
| NAs.002232 | 4 | all-match | K562 | |
IC50 | = | 13000.0 | nM | Antiproliferative activity against K562 erythroid leukemic cells was determined. | CHEMBL1130108 | |
| NAs.002232 | 4 | all-match | K562 | |
Other | = | 13.0 | uM | The concentration used to induce differentiation in K562 cells | CHEMBL1130108 | |
| NAs.002232 | 4 | all-match | K562 | |
Other | = | 40.0 | % | The ability to induce differentiation in K562 cells was estimated by determining the fraction of benzidine positive cells converted following incubation with the compound. | CHEMBL1130108 | |
| NAs.002232 | 4 | all-match | Unchecked | |
Other | = | 3.1 | % | Percentage of benzidine positive cells is divided by the concentration used. | CHEMBL1130108 | |
| NAs.002785 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 1 |  |
Ki | = | 13.0 | nM | Inhibition of human IMPDH1 by Spectrophotometry | CHEMBL1681750 | |
| NAs.002785 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
Ki | = | 30.0 | nM | Inhibition of human IMPDH2 by Spectrophotometer | CHEMBL1681750 | |
| NAs.002785 | 4 | all-match | K562 | |
IC50 | = | 4700.0 | nM | Antiproliferative activity against human K562 cells after 72 hrs by MTS assay | CHEMBL1681750 | |