显示 1 到 50 条，共 718 条数据 每页数据量:
Compound ID
Cluster
Compound Type
Target Name Img Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000000 2 ribose-match Adenosine kinase NAs.000000 IC50 = 794328.23 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000018 2 ribose-match Adenosine kinase NAs.000018 IC50 = 19.0 nM Inhibitory activity against Human Recombinant Adenosine Kinase CHEMBL1144426
NAs.000018 2 ribose-match Adenosine kinase NAs.000018 IC50 = 19.0 nM Inhibition of human adenosine kinase assessed as reduction in conversion of adenosine to AMP CHEMBL4428046
NAs.000089 2 ribose-match Adenosine kinase NAs.000089 IC50 = 300.0 nM Inhibitory activity against Human Recombinant Adenosine Kinase CHEMBL1144426
NAs.000104 2 all-match Adenosine kinase NAs.000104 IC50 = 1000.0 nM Inhibitory activity against human recombinant adenosine kinase CHEMBL1136804
NAs.000137 2 all-match Adenosine kinase NAs.000137 IC50 = 8000.0 nM Inhibition of wild-type N-terminal TEV cleavage site-fused/His-tagged Mycobacterium tuberculosis H37Rv adenosine kinase expressed in Escherichia coli BL21 (DE3) using adenosine as substrate in presence of ATP and PEP by pyruvate kinase-lactate dehydrogenase coupled UV-vis spectrophotometric method CHEMBL4393679
NAs.000137 2 all-match Adenosine kinase NAs.000137 IC50 = 170.0 nM Inhibition of recombinant human adenosine kinase CHEMBL1133459
NAs.000137 2 all-match Adenosine kinase NAs.000137 IC50 = 170.0 nM Inhibitory activity against Human Recombinant Adenosine Kinase CHEMBL1144426
NAs.000137 2 all-match Adenosine kinase NAs.000137 IC50 = 6330.0 nM Inhibition of adenosine phosphorylation in confluent IMR-32 (human neuroblastoma) cells. CHEMBL1134440
NAs.000137 2 all-match Adenosine kinase NAs.000137 IC50 = 15.0 nM In vitro inhibition of Adenosine kinase (AK) CHEMBL1134440
NAs.000137 2 all-match Adenosine kinase NAs.000137 IC50 = 15.0 nM In vitro inhibition of Adenosine kinase of rat brain cytosol. CHEMBL1133950
NAs.000140 2 ribose-match Adenosine kinase NAs.000140 IC50 = 25822.6 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000140 2 ribose-match Adenosine kinase NAs.000140 IC50 = 25800.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000197 2 ribose-match Adenosine kinase NAs.000197 IC50 = 8203.52 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000197 2 ribose-match Adenosine kinase NAs.000197 IC50 = 8200.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000238 2 ribose-match Adenosine kinase NAs.000238 IC50 = 7194.49 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000238 2 ribose-match Adenosine kinase NAs.000238 IC50 = 7500.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000270 2 ribose-match Adenosine kinase NAs.000270 IC50 = 14300.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000270 2 ribose-match Adenosine kinase NAs.000270 IC50 = 14288.94 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000301 2 ribose-match Adenosine kinase NAs.000301 IC50 = 200.0 nM Inhibitory activity against Human Recombinant Adenosine Kinase CHEMBL1144426
NAs.000320 2 ribose-match Adenosine kinase NAs.000320 IC50 = 10500.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000320 2 ribose-match Adenosine kinase NAs.000320 IC50 = 10495.42 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000389 7 ribose-match Adenosine kinase NAs.000389 Kd > 30000.0 nM Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. CHEMBL3991601
NAs.000484 2 ribose-match Adenosine kinase NAs.000484 Ki = 120.2 nM Inhibition of wild-type N-terminal TEV cleavage site-fused/His-tagged Mycobacterium tuberculosis H37Rv adenosine kinase expressed in Escherichia coli BL21 (DE3) using adenosine as substrate in presence of ATP and PEP by pyruvate kinase-lactate dehydrogenase coupled UV-vis spectrophotometric method CHEMBL4393679
NAs.000484 2 ribose-match Adenosine kinase NAs.000484 Ki = 5100.0 nM Inhibition of recombinant human adenosine kinase expressed in Escherichia coli BL21 (DE3) using adenosine as substrate in presence of ATP and PEP by pyruvate kinase-lactate dehydrogenase-coupled UV-vis spectrophotometric assay CHEMBL4393679
NAs.000502 2 ribose-match Adenosine kinase NAs.000502 IC50 = 1000.0 nM Inhibitory activity against Human Recombinant Adenosine Kinase CHEMBL1144426
NAs.000605 2 ribose-match Adenosine kinase NAs.000605 IC50 = 14996.85 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000605 2 ribose-match Adenosine kinase NAs.000605 IC50 = 15000.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000683 2 all-match Deoxyadenosine kinase NAs.000683 Kcat = 1.82 /s Activity of Staphylococcus aureus CCM 885 recombinant deoxyadenosine kinase CHEMBL1155163
NAs.000683 2 all-match Deoxyadenosine kinase NAs.000683 Km = 29200.0 nM Activity of Staphylococcus aureus CCM 885 recombinant deoxyadenosine kinase CHEMBL1155163
NAs.000683 2 all-match Deoxyadenosine kinase NAs.000683 Vmax = 4.1 U/mg Activity of Staphylococcus aureus CCM 885 recombinant deoxyadenosine kinase CHEMBL1155163
NAs.000683 2 all-match Deoxyadenosine kinase NAs.000683 Kcat/Km = 6.22 10'4/M/s Ratio of kcat to Km for Staphylococcus aureus CCM 885 recombinant deoxyadenosine kinase CHEMBL1155163
NAs.000689 2 all-match Adenosine kinase NAs.000689 Km None None nM Inhibitory activity against bovine liver adenosine Kinase; NS, NI/Ino=nonsubstrate, noninhibitor/inhibitor CHEMBL1130251
NAs.000752 2 ribose-match Adenosine kinase NAs.000752 IC50 = 20606.3 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000752 2 ribose-match Adenosine kinase NAs.000752 IC50 = 20600.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000764 2 ribose-match Adenosine kinase NAs.000764 IC50 = 8709.64 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000764 2 ribose-match Adenosine kinase NAs.000764 IC50 = 8700.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000961 2 ribose-match Adenosine kinase NAs.000961 IC50 = 10592.54 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000961 2 ribose-match Adenosine kinase NAs.000961 IC50 = 10600.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000969 2 ribose-match Adenosine kinase NAs.000969 IC50 = 2000.0 nM Inhibitory activity against Human Recombinant Adenosine Kinase CHEMBL1144426
NAs.000976 2 ribose-match Adenosine kinase NAs.000976 IC50 = 230.0 nM Inhibitory activity against Human Recombinant Adenosine Kinase CHEMBL1144426
NAs.000989 2 ribose-match Adenosine kinase NAs.000989 IC50 = 8300.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.000989 2 ribose-match Adenosine kinase NAs.000989 IC50 = 8298.51 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.001053 2 ribose-match Adenosine kinase NAs.001053 IC50 = 1000.0 nM Inhibitory activity against Human Recombinant Adenosine Kinase CHEMBL1144426
NAs.001210 2 ribose-match Adenosine kinase NAs.001210 IC50 = 90.0 nM Inhibitory activity against Human Recombinant Adenosine Kinase CHEMBL1144426
NAs.001227 2 ribose-match Adenosine kinase NAs.001227 IC50 = 8491.8 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.001227 2 ribose-match Adenosine kinase NAs.001227 IC50 = 8500.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.001258 7 all-match Adenosine kinase NAs.001258 IC50 > 100000.0 nM Inhibition of human recombinant adenosine kinase expressed in Escherichia coli CHEMBL1138458
NAs.001301 2 ribose-match Adenosine kinase NAs.001301 IC50 = 23227.37 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254
NAs.001301 2 ribose-match Adenosine kinase NAs.001301 IC50 = 23200.0 nM Inhibition of Toxoplasma gondii adenosine kinase CHEMBL3045254