| Compound ID |
Cluster
|
Compound Type
|
Target Name | Img | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000315 | 2 | all-match | Nonstructural protein 5 |  |
IC50 | = | 490.0 | nM | Inhibition of Dengue virus ribose 2'-O methyltransferase using RNA substrate after 20 mins in presence of [methyl-3H]-AdoMet by microbeta counting analysis | CHEMBL4431301 | |
| NAs.000947 | 2 | all-match | Nonstructural protein 5 |  |
IC50 | = | 41.0 | nM | Inhibition of Dengue virus ribose 2'-O methyltransferase using RNA substrate after 20 mins in presence of [methyl-3H]-AdoMet by microbeta counting analysis | CHEMBL4431301 | |
| NAs.001060 | 2 | ribose-match | Nonstructural protein 5 |  |
Ki | = | 170.0 | nM | Inhibition of N-terminal GST tagged recombinant Dengue virus 3 2'-O methyltransferase expressed in Escherichia coli BL21 cells by scintillation counting analysis | CHEMBL4431301 | |
| NAs.003896 | 0 | all-match | Nonstructural protein 5 |  |
IC50 | = | 360.0 | nM | Inhibition of Dengue virus 2 NS5 full length RdRp activity using RNA as template/primer assessed as inhibition of [alpha3P]GTP incorporation by SDS-PAGE analysis | CHEMBL4118212 | |
| NAs.004305 | 0 | all-match | Nonstructural protein 5 |  |
IC50 | = | 1600.0 | nM | Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 mins | CHEMBL4118212 | |
| NAs.004310 | 0 | all-match | Nonstructural protein 5 |  |
IC50 | = | 2000.0 | nM | Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 mins | CHEMBL4118212 | |
| NAs.004422 | 0 | all-match | Nonstructural protein 5 |  |
IC50 | = | 5000.0 | nM | Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 mins | CHEMBL4118212 | |
| NAs.004450 | 0 | all-match | Nonstructural protein 5 |  |
IC50 | = | 18000.0 | nM | Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 mins | CHEMBL4118212 | |
| NAs.004497 | 0 | all-match | Nonstructural protein 5 |  |
IC50 | > | 20000.0 | nM | Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 mins | CHEMBL4118212 | |
| NAs.004597 | 0 | all-match | Nonstructural protein 5 |  |
IC50 | = | 15900.0 | nM | Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 mins | CHEMBL4118212 | |
| NAs.008971 | 2 | all-match | Nonstructural protein 5 |  |
Inhibition | None | None | % | Inhibition of Dengue virus NS5 2'O-MTase expressed in Escherichia coli at upto 50 uM | CHEMBL5154878 | |