Showing 1 to 44 of 44 entries Per page:
Compound ID
Cluster
Compound Type
Target/Cell Structure Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000046 2 all-match Adenosine A1 receptor NAs.000046 Other = 42.8 % Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.000046 2 all-match Adenosine A2a receptor NAs.000046 Ki = 3900.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.000046 2 all-match Adenosine A3 receptor NAs.000046 Ki = 257.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000046 2 all-match Adenosine A2a receptor NAs.000046 Other = 100.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor in CHO cells using cAMP assay CHEMBL1135807
NAs.000046 2 all-match Adenosine A3 receptor NAs.000046 Other = 41.0 % % inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 30 uM CHEMBL1135807
NAs.000046 2 all-match Trypanosoma brucei rhodesiense NAs.000046 IC50 = 5000.0 nM Antitrypanosomal activity against bloodstream forms of Trypanosoma brucei rhodesiense STIB900 trypomastigotes after 72 hrs by alamar blue assay CHEMBL3997846
NAs.000046 2 all-match Unchecked NAs.000046 Other = 27.0 None Selectivity index, ratio of IC50 for rat L6 cells to IC50 for bloodstream forms of Trypanosoma brucei rhodesiense STIB900 trypomastigotes CHEMBL3997846
NAs.000046 2 all-match Trypanosoma cruzi NAs.000046 IC50 = 88000.0 nM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen strain C2C4 amastigote forms harboring LacZ infected in rat L6 cells after 96 hrs by CPRG/Nonidet reagent based photometric method CHEMBL3997846
NAs.000046 2 all-match Unchecked NAs.000046 Other = 2.0 None Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma cruzi Tulahuen strain C2C4 amastigote forms harboring LacZ infected in rat L6 cells CHEMBL3997846
NAs.000046 2 all-match Leishmania donovani NAs.000046 IC50 = 132000.0 nM Antileishmanial activity against Leishmania donovani MHOM/SD/62/ISCL2D axenic amastigotes after 72 hrs by alamar blue assay CHEMBL3997846
NAs.000046 2 all-match Unchecked NAs.000046 Other = 1.0 None Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Leishmania donovani MHOM/SD/62/ISCL2D axenic amastigotes CHEMBL3997846
NAs.000187 2 all-match Adenosine A3 receptor NAs.000187 Other = 10.0 % % inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 30 uM CHEMBL1135807
NAs.000187 2 all-match Adenosine A2a receptor NAs.000187 Other = 30.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000187 2 all-match Adenosine A2a receptor NAs.000187 Ki = 440.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.000187 2 all-match Adenosine A1 receptor NAs.000187 Ki = 1050.0 nM Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane CHEMBL1135807
NAs.000187 2 all-match Adenosine A3 receptor NAs.000187 Ki = 558.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000230 2 all-match Adenosine A1 receptor NAs.000230 Ki = 386.0 nM Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane CHEMBL1135807
NAs.000230 2 all-match Adenosine A2a receptor NAs.000230 Ki = 1200.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.000230 2 all-match Adenosine A3 receptor NAs.000230 Ki = 395.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000230 2 all-match Adenosine A2a receptor NAs.000230 Other = 100.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000230 2 all-match Adenosine A3 receptor NAs.000230 Other = 14.0 % % inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 30 uM CHEMBL1135807
NAs.000334 2 all-match Adenosine A3 receptor NAs.000334 Ki = 297.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000334 2 all-match Adenosine A3 receptor NAs.000334 Other = 68.0 % % inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 30 uM CHEMBL1135807
NAs.000334 2 all-match Adenosine A2a receptor NAs.000334 EC50 = 5400.0 nM G-protein activation in human Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000334 2 all-match Adenosine A2a receptor NAs.000334 Other = 112.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor expressed in CHO cells using cAMP assay CHEMBL1135807
NAs.000334 2 all-match Adenosine A2a receptor NAs.000334 Ki = 4200.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.000334 2 all-match ADMET NAs.000334 Other = 9.1 % Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 1 uM CHEMBL1130967
NAs.000334 2 all-match ADMET NAs.000334 Other = 12.2 % Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 60 uM CHEMBL1130967
NAs.000334 2 all-match ADMET NAs.000334 Other = 12.0 % Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 30 uM CHEMBL1130967
NAs.000334 2 all-match ADMET NAs.000334 Other = 12.1 % Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 10 uM CHEMBL1130967
NAs.000334 2 all-match Adenosine A1 receptor NAs.000334 Other = 36.1 % Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.000542 2 all-match Adenosine A2a receptor NAs.000542 Other = 100.0 % Maximum level of G-protein activation (Emax) compared to CGS 21680 through Adenosine A2A receptor in CHO cells using cAMP assay CHEMBL1135807
NAs.000542 2 all-match Adenosine A3 receptor NAs.000542 Ki = 546.0 nM Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement. CHEMBL1135807
NAs.000542 2 all-match Adenosine A3 receptor NAs.000542 Other = 17.0 % % inhibition of forskolin induced (10 uM) cAMP production compared to C1-IB-MECA through Adenosine A3 receptor expressed in CHO cells at 30 uM CHEMBL1135807
NAs.000542 2 all-match Adenosine A1 receptor NAs.000542 Other = 56.2 % Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane at 10e-5 M CHEMBL1135807
NAs.000542 2 all-match Adenosine A2a receptor NAs.000542 Ki = 820.0 nM Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement. CHEMBL1135807
NAs.001038 2 all-match DNA (cytosine-5)-methyltransferase 1 NAs.001038 IC50 = 21000.0 nM Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells CHEMBL1151871
NAs.001038 2 all-match DNA (cytosine-5)-methyltransferase 3B NAs.001038 IC50 = 256000.0 nM Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells CHEMBL1151871
NAs.001164 4 all-match Unchecked NAs.001164 IC50 > 50000.0 nM Inhibition of horse liver lactate dehydrogenase CHEMBL1138261
NAs.001164 4 all-match Unchecked NAs.001164 IC50 > 50000.0 nM Inhibition of horse liver malate dehydrogenase CHEMBL1138261
NAs.001164 4 all-match Inosine-5'-monophosphate dehydrogenase 1 NAs.001164 Ki = 19.0 nM Inhibition of human IMPDH type 1 CHEMBL1138261
NAs.001164 4 all-match Inosine-5'-monophosphate dehydrogenase 2 NAs.001164 Ki = 84.0 nM Inhibition of human IMPDH type 2 CHEMBL1138261
NAs.001164 4 all-match Unchecked NAs.001164 IC50 None None None Inhibition of horse liver alcohol dehydrogenase CHEMBL1138261
NAs.001164 4 all-match Unchecked NAs.001164 Ki = 20.0 nM Inhibition of human IMPDH CHEMBL1152430