| Compound ID |
Cluster
|
Compound Type
|
Target/Cell | Structure | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000373 | 4 | ribose-match | Unchecked |  |
IC50 | None | None | None | Inhibition of horse liver alcohol dehydrogenase | CHEMBL1138261 | |
| NAs.000373 | 4 | ribose-match | Inosine-5'-monophosphate dehydrogenase 1 | |
Ki | = | 45.0 | nM | Inhibition of human IMPDH type 1 | CHEMBL1138261 | |
| NAs.000373 | 4 | ribose-match | Inosine-5'-monophosphate dehydrogenase 2 | |
Ki | = | 169.0 | nM | Inhibition of human IMPDH type 2 | CHEMBL1138261 | |
| NAs.000373 | 4 | ribose-match | Unchecked | |
IC50 | = | 30000.0 | nM | Inhibition of horse liver malate dehydrogenase | CHEMBL1138261 | |
| NAs.000373 | 4 | ribose-match | Unchecked | |
IC50 | > | 50000.0 | nM | Inhibition of horse liver lactate dehydrogenase | CHEMBL1138261 | |
| NAs.000569 | 4 | all-match | Alcohol dehydrogenase |  |
Other | = | 27000.0 | nM | Dissociation constant from Alcohol dehydrogenase | CHEMBL1124735 | |
| NAs.000569 | 4 | all-match | P388 | |
Other | = | 7.5 | uM | Cytotoxicity against P388 cells in culture | CHEMBL1122938 | |
| NAs.000569 | 4 | all-match | Unchecked | |
Ki | = | 130.0 | nM | Uncompetitive Inhibitory activity against Inosine-5'-monophosphate dehydrogenase using IMP as viable substrate | CHEMBL1122938 | |
| NAs.000569 | 4 | all-match | Unchecked | |
Ki | = | 240.0 | nM | Noncompetitive inhibitory activity against Inosine-5'-monophosphate dehydrogenase using NAD as viable substrate | CHEMBL1122938 | |
| NAs.000569 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
Other | = | 0.19 | uM | Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from intercept of Michaelis-Menten plot | CHEMBL1128279 | |
| NAs.000569 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
Other | = | 0.3 | uM | Inhibitory binding constant was determined against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) from slope of Michaelis-Menten plot | CHEMBL1128279 | |
| NAs.000569 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 1 | |
Ki | = | 710.0 | nM | The compound was tested for the inhibition towards IMP(Inosine 5'-monophosphate) substrate of Inosine-5'-monophosphate dehydrogenase 1 | CHEMBL1131220 | |
| NAs.000569 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 1 | |
Ki | = | 470.0 | nM | The compound was tested for the inhibition towards NMD (Nicotinamide adenine dinucleotide) substrate of Inosine-5'-monophosphate dehydrogenase 1 | CHEMBL1131220 | |
| NAs.000569 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
Ki | = | 430.0 | nM | The compound was tested for the inhibition towards IMP(Inosine 5'-monophosphate) substrate of Inosine-5'-monophosphate dehydrogenase 2 | CHEMBL1131220 | |
| NAs.000569 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
IC50 | = | 90.0 | nM | The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 | CHEMBL1130108 | |
| NAs.000569 | 4 | all-match | Unchecked | |
Ki | = | 120.0 | nM | Inhibition of inosine monophosphate dehydrogenase (IMPDH) enzyme by Non-competitive inhibition | CHEMBL1126721 | |
| NAs.000569 | 4 | all-match | Malate dehydrogenase cytoplasmic | |
Ki | = | 36300.0 | nM | In vitro inhibitory activity against pig heart cytoplasmic malate dehydrogenase (MDH) | CHEMBL1124735 | |
| NAs.000569 | 4 | all-match | K562 | |
IC50 | = | 3700.0 | nM | Antiproliferative activity against K562 erythroid leukemic cells was determined. | CHEMBL1130108 | |
| NAs.000569 | 4 | all-match | K562 | |
Other | = | 70.0 | % | The ability to induce differentiation in K562 cells was estimated by determining the fraction of benzidine positive cells converted following incubation with the compound. | CHEMBL1130108 | |
| NAs.000569 | 4 | all-match | Unchecked | |
Other | = | 7.7 | % | Percentage of benzidine positive cells is divided by the concentration used. | CHEMBL1130108 | |
| NAs.000569 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase (IMPDH) | |
Other | = | 110.0 | nM | Inhibition of human IMPDH | CHEMBL1145329 | |
| NAs.000569 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 1 | |
Ki | = | 110.0 | nM | Inhibition of human IMPDH1 by Spectrophotometry | CHEMBL1681750 | |
| NAs.000569 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
Ki | = | 110.0 | nM | Inhibition of human IMPDH2 by Spectrophotometer | CHEMBL1681750 | |
| NAs.000569 | 4 | all-match | K562 | |
IC50 | = | 3700.0 | nM | Antiproliferative activity against human K562 cells assessed as release of tiazofurin after 72 hrs | CHEMBL1681750 | |
| NAs.000569 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
Ki | = | 440.0 | nM | The compound was tested for the inhibition towards NMD (Nicotinamide adenine dinucleotide) substrate of Inosine-5'-monophosphate dehydrogenase 2 | CHEMBL1131220 | |
| NAs.000569 | 4 | all-match | L-lactate dehydrogenase B chain | |
Ki | = | 25200.0 | nM | In vitro inhibitory activity against pig heart lactate dehydrogenase (LDH) | CHEMBL1124735 | |
| NAs.000569 | 4 | all-match | K562 | |
Other | = | 15.0 | uM | The concentration used to induce differentiation in K562 cells | CHEMBL1130108 | |
| NAs.000569 | 4 | all-match | Glutamate dehydrogenase | |
Ki | = | 4500.0 | nM | In vitro inhibitory activity against bovine liver glutamate dehydrogenase (GDH) | CHEMBL1124735 | |
| NAs.000569 | 4 | all-match | K562 | |
Other | = | 35.0 | % | Compound effect on differentiation of K562 cells, % of benzidine positive cells at 14 uM | CHEMBL1135710 | |
| NAs.000569 | 4 | all-match | K562 | |
Other | = | 2.5 | % | Compound effect on differentiation of K562 cells, % of benzidine positive cells at 1.0 uM | CHEMBL1135710 | |
| NAs.000569 | 4 | all-match | K562 | |
IC50 | = | 3700.0 | nM | Tested for inhibition of growth in human erythroleukemia K-562 cells. | CHEMBL1130411 | |
| NAs.000569 | 4 | all-match | K562 | |
Other | = | 80.0 | % | Inhibition of growth in human erythroleukemia K-562 cells (% of untreated control) | CHEMBL1130411 | |
| NAs.000569 | 4 | all-match | K562 | |
Other | = | 50.0 | % | Differentiation of K-562 cells at 7.5 uM with out coadministration of guanosine | CHEMBL1130411 | |
| NAs.000569 | 4 | all-match | K562 | |
Other | = | 15.0 | % | Differentiation of K-562 cells at 7.5 uM with coadministration of guanosine | CHEMBL1130411 | |
| NAs.000569 | 4 | all-match | Alcohol dehydrogenase | |
Ki | = | 26500.0 | nM | In vitro inhibitory activity against horse liver Alcohol dehydrogenase (ADH) | CHEMBL1124735 | |
| NAs.000569 | 4 | all-match | K562 | |
Other | = | 70.0 | % | Differentiation of K-562 cells at 15 uM with out coadministration of guanosine | CHEMBL1130411 | |
| NAs.000569 | 4 | all-match | Unchecked | |
Ki | = | 300.0 | nM | Inhibition of partially purified preparation of Inosine-5'-monophosphate dehydrogenase from P388 leukemic cells with enzymatically synthesized dinucleotide | CHEMBL1122493 | |
| NAs.000569 | 4 | all-match | K562 | |
Other | = | 30.0 | % | Differentiation of K-562 cells at 15 uM with coadministration of guanosine | CHEMBL1130411 | |
| NAs.000569 | 4 | all-match | P388 | |
IC50 | = | 2100.0 | nM | Cytotoxicity against P388 cells with enzymatically synthesized dinucleotide | CHEMBL1122493 | |
| NAs.000569 | 4 | all-match | P388 | |
IC50 | = | 3100.0 | nM | Cytotoxicity against P388 cells with chemically synthesized dinucleotide | CHEMBL1122493 | |
| NAs.000569 | 4 | all-match | Mus musculus | |
Other | = | 12.6 | None | In vivo antitumor activity against mice bearing P388 cells | CHEMBL1122493 | |
| NAs.000569 | 4 | all-match | Unchecked | |
Other | = | 135.0 | % | Tested for in vivo antitumor activity in mice expressed as percentage of treated/control | CHEMBL1122493 | |
| NAs.000569 | 4 | all-match | P388 | |
Other | = | 2.1 | uM | The cytotoxic concentration against P388 leukemia cell | CHEMBL1123434 | |
| NAs.000569 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 2 | |
Ki | = | 240.0 | nM | Compound was tested for inhibitory activity against Inosine-5'-monophosphate dehydrogenase, the type of inhibition in not competitive | CHEMBL1123434 | |
| NAs.000569 | 4 | all-match | Unchecked | |
Other | = | 100.0 | % | Compound was tested for its degradation by TAD-phosphodiesterase | CHEMBL1123434 | |
| NAs.000569 | 4 | all-match | Unchecked | |
Other | = | 100.0 | % | Compound was tested for its degradation by venom phosphodiesterase | CHEMBL1123434 | |
| NAs.000569 | 4 | all-match | Unchecked | |
Other | None | None | None | Compound tested for the inhibition of IMP-dehydrogenase causing a profound depletion of GMP anf accumulation of IMP; Active | CHEMBL1123746 | |
| NAs.000569 | 4 | all-match | Unchecked | |
Ki | = | 120.0 | nM | Inhibition of partially purified preparation of Inosine-5'-monophosphate dehydrogenase from P388 leukemic cells with chemically synthesized dinucleotide | CHEMBL1122493 | |
| NAs.000574 | 4 | all-match | Unchecked |  |
IC50 | > | 50000.0 | nM | Inhibition of horse liver lactate dehydrogenase | CHEMBL1138261 | |
| NAs.000574 | 4 | all-match | Inosine-5'-monophosphate dehydrogenase 1 | |
Ki | = | 7.0 | nM | Inhibition of human IMPDH type 1 | CHEMBL1138261 | |