NA-DB

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Compound ID	Cluster 0 1 2 3 4 5 6 7 8 9	Compound Type ALL-match base match ribose match	Target Name	Img	Activity				Assay Description	Source
Compound ID	Cluster 0 1 2 3 4 5 6 7 8 9	Compound Type ALL-match base match ribose match	Target Name	Img	Type Ki Activity Km Relative Vmax Stability Drug metabolism Vmax Relative activity ([I]/[S]0.5) Ratio Compound remaining k cat/Km k cat Inhibition IC50 NS Kcat/Km Kcat Ka REA K	Relation = None >	Value	Unit nM % None uM min-1 unit-1 10'-3umol/min/U M min-1 mg-1 uM min-1 uM min-1 (mg of protein)-1 nmol/min/mg uM-1 s-1 s-1 10'-4umol/min/U /s/microM /s M-1 10'-2umol/min/U /min 10'-4M/min 10'-5M/min 10'-3/min	Assay Description	Source
NAs.000001	7	all-match	Adenosine deaminase		Ki	=	6.4	nM	Tested for binding affinity against calf intestinal Adenosine Deaminase (ADA)	CHEMBL1127396
NAs.000004	2	all-match	Adenosine deaminase		Ki	=	320.0	nM	Binding affinity (Ki) at calf intestinal adenosine deaminase.	CHEMBL1126223
NAs.000031	2	all-match	Adenosine deaminase		Ki	=	133.0	nM	Compound was evaluated for inhibition of calf intestinal mucosa adenosine deaminase (ADA)	CHEMBL1130858
NAs.000031	2	all-match	Adenosine deaminase		Ki	=	133.0	nM	Inhibition of Adenosine deaminase (ADA) of calf intestine	CHEMBL1133542
NAs.000032	2	all-match	Adenosine deaminase		Activity	=	100.0	%	Activity of calf intestine adenosine deaminase assessed as deamination after 24 hrs	CHEMBL1138503
NAs.000032	2	all-match	Adenosine deaminase		Activity	=	100.0	%	Activity of calf intestine adenosine deaminase assessed as deamination after 48 hrs	CHEMBL1138503
NAs.000039	7	all-match	Adenosine deaminase		Km	=	200000.0	nM	Michaelis rate constant is determined by the Lineweaver and Burk method against adenosine deaminase	CHEMBL1134666
NAs.000039	7	all-match	Adenosine deaminase		Relative Vmax	=	1.5	None	Maximum velocity constant of the rate of deamination was determined against adenosine deaminase	CHEMBL1134666
NAs.000039	7	all-match	Adenosine deaminase		Ki	=	8300.0	nM	Inhibitory activity against adenosine deaminase	CHEMBL1134666
NAs.000047	2	all-match	Adenosine deaminase		Ki	=	29800.0	nM	Inhibition of calf placental adenosine deaminase by Lineweaver-Burk plot analysis	CHEMBL1649089
NAs.000063	2	base-match	Adenosine deaminase		Stability	None	None	%	Activity of calf mucosal adenosine deaminase assessed as enzyme-mediated drug metabolism by liquid chromatographic analysis	CHEMBL3228031
NAs.000069	2	all-match	Adenosine deaminase		Ki	=	6.2	nM	Inhibition of bovine adenosine deaminase pre-incubated for 5 mins before adenosine addition	CHEMBL4177582
NAs.000090	2	all-match	Adenosine deaminase		Ki	=	33000.0	nM	Inhibition of calf intestine adenosine deaminase by Lineweaver-Burk plot analysis	CHEMBL1649089
NAs.000149	2	all-match	Adenosine deaminase		Drug metabolism	None	None	None	Drug metabolism assessed as recombinant human ADA-mediated inosine metabolite formation at 100 uM measured every 15 mins for 10 hrs by spectrophotometric analysis	CHEMBL3108778
NAs.000149	2	all-match	Adenosine deaminase		Drug metabolism	None	None	None	Drug metabolism assessed as recombinant human ADA-mediated inosine metabolite formation at 100 uM measured every 15 mins for 10 hrs by spectrophotometric analysis in presence of deoxycoformycin	CHEMBL3108778
NAs.000167	2	all-match	Adenosine deaminase		Ki	=	32100.0	nM	Inhibition of calf placental adenosine deaminase by Lineweaver-Burk plot analysis	CHEMBL1649089
NAs.000170	7	all-match	Adenosine deaminase		Km	=	553600.0	nM	Michaelis-Menten constant for Calf intestinal mucosa adenosine deaminase was determined	CHEMBL1127724
NAs.000170	7	all-match	Adenosine deaminase		Vmax	=	0.000104	uM min-1 unit-1	Vmax for Calf intestinal mucosa adenosine deaminase was determined	CHEMBL1127724
NAs.000170	7	all-match	Adenosine deaminase		Km	=	553600.0	nM	Substrate activity at calf Intestinal mucosa adenosine deaminase assessed as km by Lineweaver-Burk plot analysis	CHEMBL4613261
NAs.000170	7	all-match	Adenosine deaminase		Vmax	=	1.04	10'-3umol/min/U	Substrate activity at calf Intestinal mucosa adenosine deaminase assessed as Vmax by Lineweaver-Burk plot analysis	CHEMBL4613261
NAs.000174	2	all-match	Adenosine deaminase		Stability	None	None	%	Activity of calf mucosal adenosine deaminase assessed as enzyme-mediated drug metabolism by liquid chromatographic analysis	CHEMBL3228031
NAs.000177	2	all-match	Adenosine deaminase		Stability	None	None	%	Activity of calf mucosal adenosine deaminase assessed as enzyme-mediated drug metabolism by liquid chromatographic analysis	CHEMBL3228031
NAs.000183	2	all-match	Adenosine deaminase		Km	=	33000.0	nM	Kinetic parameter was determined against adenosine deaminase expressed as Km	CHEMBL1123068
NAs.000183	2	all-match	Adenosine deaminase		Vmax	=	119.0	M min-1 mg-1	Kinetic parameter was determined against adenosine deaminase expressed as Vmax	CHEMBL1123068
NAs.000183	2	all-match	Adenosine deaminase		Km	=	33000.0	nM	Kinetic parameter in calf intestine adenosine deaminase.	CHEMBL1122375
NAs.000183	2	all-match	Adenosine deaminase-like protein		Activity	None	None	None	Activity of recombinant human ADAL1 expressed in Escherichia coli by UV-spectrophotometry	CHEMBL1811779
NAs.000193	2	all-match	Adenosine deaminase		Ki	=	4000.0	nM	Inhibitory constant against adenosine deaminase in 0.05 M sodium phosphate buffer at pH 7.0 was determined before heating	CHEMBL1121634
NAs.000200	2	all-match	Adenosine deaminase		Vmax	=	0.41	uM min-1	Vmax by adenosine deaminase	CHEMBL1126199
NAs.000200	2	all-match	Adenosine deaminase		Km	=	530000.0	nM	Km by adenosine deaminase	CHEMBL1126199
NAs.000200	2	all-match	Adenosine deaminase		Vmax	=	0.52	uM min-1	Vmax by adenosine deaminase	CHEMBL1126199
NAs.000200	2	all-match	Adenosine deaminase		Km	=	18500.0	nM	Km by adenosine deaminase	CHEMBL1126199
NAs.000222	2	all-match	Adenosine deaminase		Stability	None	None	%	Activity of calf mucosal adenosine deaminase assessed as enzyme-mediated drug metabolism by liquid chromatographic analysis	CHEMBL3228031
NAs.000226	2	all-match	Adenosine deaminase		Stability	None	None	%	Stability of the compound assessed as calf mucosal adenosine deaminase-mediated drug metabolism	CHEMBL3243926
NAs.000227	2	all-match	Adenosine deaminase		Ki	=	1.02	nM	Compound was evaluated for inhibition of calf intestinal mucosa adenosine deaminase (ADA)	CHEMBL1130858
NAs.000227	2	all-match	Adenosine deaminase		Ki	=	1.02	nM	Inhibition of Adenosine deaminase (ADA) of calf intestine	CHEMBL1133542
NAs.000256	2	all-match	Adenosine deaminase		Stability	None	None	%	Activity of calf mucosal adenosine deaminase assessed as enzyme-mediated drug metabolism by liquid chromatographic analysis	CHEMBL3228031
NAs.000259	2	all-match	Adenosine deaminase		Ki	=	7.0	nM	Inhibition of calf intestinal adenosine deaminase	CHEMBL1125631
NAs.000259	2	all-match	Adenosine deaminase		Ki	=	4.3	nM	Inhibition constant (Ki) against Human erythrocyte adenosine deaminase	CHEMBL1124034
NAs.000259	2	all-match	Adenosine deaminase		Ki	=	7.0	nM	Inhibition constant (Ki) against calf intestine adenosine deaminase	CHEMBL1124034
NAs.000259	2	all-match	Adenosine deaminase		Ki	=	10.0	nM	Binding affinity against Adenosine deaminase from calf intestinal mucosa was determined	CHEMBL1133835
NAs.000259	2	all-match	Adenosine deaminase		Ki	=	7.0	nM	In vitro inhibition of adenosine deaminase isolated from calf intestine.	CHEMBL1127841
NAs.000259	2	all-match	Adenosine deaminase		Ki	=	7.0	nM	Binding affinity against calf intestine adenosine deaminase enzyme	CHEMBL1122580
NAs.000259	2	all-match	Adenosine deaminase		Ki	=	4.0	nM	Binding affinity (Ki) at calf intestinal adenosine deaminase.	CHEMBL1126223
NAs.000259	2	all-match	Adenosine deaminase		Ki	=	3.7	nM	Inhibition constant against human adenosine deaminase was determined	CHEMBL1136651
NAs.000259	2	all-match	Adenosine deaminase		Relative activity	=	1.0	None	Inhibition of adenosine deaminase by the compound relative to E/THNA	CHEMBL1130254
NAs.000259	2	all-match	Adenosine deaminase		([I]/[S]0.5)	=	0.00042	None	Adenosine deaminase inhibition index	CHEMBL1130254
NAs.000259	2	all-match	Adenosine deaminase		Ki	=	0.4	nM	Compound was evaluated for the inhibition of adenosine deaminase	CHEMBL1121750
NAs.000259	2	all-match	Adenosine deaminase		Ki	=	500.0	nM	Compound was evaluated for the inhibition of adenosine deaminase	CHEMBL1121750
NAs.000259	2	all-match	Adenosine deaminase		Ki	=	1.3	nM	Ability to inhibit calf intestinal adenosine deaminase (ADA); No data	CHEMBL1122062
NAs.000260	2	all-match	Adenosine deaminase		Km	=	140000.0	nM	Kinetic constant (Km) for the deamination of compound by adenosine deaminase	CHEMBL1132757