显示 1 到 50 条，共 204 条数据 每页数据量:
Compound ID
Cluster
Compound Type
Target Name Img Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000389 7 ribose-match Deoxycytidine kinase NAs.000389 Kd > 30000.0 nM Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. CHEMBL3991601
NAs.000683 2 all-match Deoxycytidine kinase NAs.000683 Kcat = 2.1 /s Activity of human wild type deoxycytidine kinase in presence of ATP CHEMBL1155044
NAs.000683 2 all-match Deoxycytidine kinase NAs.000683 Km = 115000.0 nM Activity of human wild type deoxycytidine kinase in presence of ATP CHEMBL1155044
NAs.000683 2 all-match Deoxycytidine kinase NAs.000683 Kcat = 0.37 /s Activity of human wild type deoxycytidine kinase in presence of UTP CHEMBL1155044
NAs.000683 2 all-match Deoxycytidine kinase NAs.000683 Km = 8500.0 nM Activity of human wild type deoxycytidine kinase in presence of UTP CHEMBL1155044
NAs.000683 2 all-match Deoxycytidine kinase NAs.000683 Ratio = 0.0182 /s/microM Ratio of Kcat for human wild type deoxycytidine kinase to Km for human wild type deoxycytidine kinase in presence of ATP CHEMBL1155044
NAs.000683 2 all-match Deoxycytidine kinase NAs.000683 Ratio = 0.0435 /s/microM Ratio of Kcat for human wild type deoxycytidine kinase to Km for human wild type deoxycytidine kinase in presence of UTP CHEMBL1155044
NAs.000689 2 all-match Deoxycytidine kinase NAs.000689 Km = 620000.0 nM Inhibitory activity against human deoxycytidine kinase CHEMBL1130251
NAs.002770 7 ribose-match Deoxycytidine kinase NAs.002770 Kd > 30000.0 nM Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. CHEMBL3991601
NAs.003005 0 all-match Deoxycytidine kinase NAs.003005 Ki = 1100000.0 nM Inhibitory affect against rabbit deoxycytidine kinase CHEMBL1124944
NAs.003005 0 all-match Deoxycytidine kinase NAs.003005 Ki = 4600000.0 nM Inhibitory affect against rabbit deoxycytidine kinase and represented as molt/4F kinase. CHEMBL1124944
NAs.003182 7 base-match Deoxycytidine kinase NAs.003182 EC50 = 390.0 nM Inhibition of deoxycytidine kinase-mediated arabinoside C-induced cytotoxicity CHEMBL1154362
NAs.003182 7 base-match Deoxycytidine kinase NAs.003182 IC50 = 49.0 nM Inhibition of human deoxycytidine kinase by lysate filter binding assay CHEMBL1154362
NAs.003184 7 all-match Deoxycytidine kinase NAs.003184 Inhibition None None % Irreversible inhibition of Walker 256 rat tumor deoxycytidine kinase by [3H]deoxycytidine binding assay CHEMBL3271948
NAs.003196 0 all-match Deoxycytidine kinase NAs.003196 Activity None None None Activity at recombinant dCK (unknown origin) at 100 uM by HPLC analysis CHEMBL3108757
NAs.003271 7 base-match Deoxycytidine kinase NAs.003271 Kd > 30000.0 nM Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. CHEMBL3991601
NAs.003274 2 all-match Deoxycytidine kinase NAs.003274 Kcat = 0.6 /s Activity of human wild type deoxycytidine kinase in presence of ATP CHEMBL1155044
NAs.003274 2 all-match Deoxycytidine kinase NAs.003274 Km = 78000.0 nM Activity of human wild type deoxycytidine kinase in presence of ATP CHEMBL1155044
NAs.003274 2 all-match Deoxycytidine kinase NAs.003274 Kcat = 0.37 /s Activity of human wild type deoxycytidine kinase in presence of UTP CHEMBL1155044
NAs.003274 2 all-match Deoxycytidine kinase NAs.003274 Km = 5100.0 nM Activity of human wild type deoxycytidine kinase in presence of UTP CHEMBL1155044
NAs.003274 2 all-match Deoxycytidine kinase NAs.003274 Ratio = 0.0077 /s/microM Ratio of Kcat for human wild type deoxycytidine kinase to Km for human wild type deoxycytidine kinase in presence of ATP CHEMBL1155044
NAs.003274 2 all-match Deoxycytidine kinase NAs.003274 Ratio = 0.0726 /s/microM Ratio of Kcat for human wild type deoxycytidine kinase to Km for human wild type deoxycytidine kinase in presence of UTP CHEMBL1155044
NAs.003485 2 ribose-match Deoxycytidine kinase NAs.003485 Kd > 30000.0 nM Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. CHEMBL3991601
NAs.003551 7 all-match Deoxycytidine kinase NAs.003551 Km = 195000.0 nM Inhibitory activity against Cytidine Kinase CHEMBL1130251
NAs.003633 0 all-match Deoxycytidine kinase NAs.003633 Activity = 85.0 % Inhibitory activity against deoxycytidine kinase from L1210 cells CHEMBL1122407
NAs.003633 0 all-match Deoxycytidine kinase NAs.003633 Activity = 89.0 % Inhibitory activity against deoxycytidine kinase from L1210 cells CHEMBL1122407
NAs.003706 0 all-match Deoxycytidine kinase NAs.003706 Km = 6600.0 nM Activity of human dCK expressed in HepG2 cells assessed as phosphorylation by coupled enzyme assay CHEMBL1142170
NAs.003706 0 all-match Deoxycytidine kinase NAs.003706 Kcat/Km = 0.0014 /uM/s Ratio of Kcat to Km for human dCK expressed in HepG2 cells CHEMBL1142170
NAs.003706 0 all-match Deoxycytidine kinase NAs.003706 Kcat = 0.009 /s Activity of human dCK expressed in HepG2 cells assessed as phosphorylation by coupled enzyme assay CHEMBL1142170
NAs.003793 6 all-match Deoxycytidine kinase NAs.003793 Activity = 86.0 % Inhibitory activity against deoxycytidine kinase from L1210 cells CHEMBL1122407
NAs.003793 6 all-match Deoxycytidine kinase NAs.003793 Activity = 78.0 % Inhibitory activity against deoxycytidine kinase from L1210 cells CHEMBL1122407
NAs.003820 0 all-match Deoxycytidine kinase NAs.003820 Km = 81200.0 nM Activity at human recombinant deoxycytidine kinase expressed in HepG2 cells CHEMBL1208712
NAs.003820 0 all-match Deoxycytidine kinase NAs.003820 Kcat = 0.016 /s Activity at human recombinant deoxycytidine kinase expressed in HepG2 cells CHEMBL1208712
NAs.003820 0 all-match Deoxycytidine kinase NAs.003820 Kcat/Km = 1.9 10'-4/uM/s Ratio of Kcat to Km for cloned 2'-deoxycytidine kinase in human HepG2 cells assessed as formation of formation of PS-6130 monophosphate by spectrophotometry CHEMBL1152990
NAs.003820 0 all-match Deoxycytidine kinase NAs.003820 Kcat/Km = 1.9 10'-4/uM/s Ratio of Kcat/Km for human recombinant deoxycytidine kinase CHEMBL1208712
NAs.003820 0 all-match Deoxycytidine kinase NAs.003820 Kcat/Km = 0.00019 /uM/s Ratio of Kcat to Km for human dCK expressed in HepG2 cells CHEMBL1142170
NAs.003820 0 all-match Deoxycytidine kinase NAs.003820 Km = 81200.0 nM Activity of human dCK expressed in HepG2 cells assessed as phosphorylation by coupled enzyme assay CHEMBL1142170
NAs.003820 0 all-match Deoxycytidine kinase NAs.003820 Kcat = 0.016 /s Activity of human dCK expressed in HepG2 cells assessed as phosphorylation by coupled enzyme assay CHEMBL1142170
NAs.003824 0 all-match Deoxycytidine kinase NAs.003824 Km = 46200.0 nM Activity of human dCK expressed in HepG2 cells assessed as phosphorylation by coupled enzyme assay CHEMBL1142170
NAs.003824 0 all-match Deoxycytidine kinase NAs.003824 Kcat/Km = 0.001 /uM/s Ratio of Kcat to Km for human dCK expressed in HepG2 cells CHEMBL1142170
NAs.003824 0 all-match Deoxycytidine kinase NAs.003824 Kcat = 0.048 /s Activity of human dCK expressed in HepG2 cells assessed as phosphorylation by coupled enzyme assay CHEMBL1142170
NAs.003860 7 all-match Deoxycytidine kinase NAs.003860 Inhibition None None % Irreversible inhibition of Walker 256 rat tumor deoxycytidine kinase by [3H]deoxycytidine binding assay CHEMBL3271948
NAs.003883 7 all-match Deoxycytidine kinase NAs.003883 Inhibition None None % Irreversible inhibition of Walker 256 rat tumor deoxycytidine kinase by [3H]deoxycytidine binding assay CHEMBL3271948
NAs.003892 0 all-match Deoxycytidine kinase NAs.003892 Km = 914000.0 nM Activity of human dCK expressed in HepG2 cells assessed as phosphorylation by coupled enzyme assay CHEMBL1142170
NAs.003892 0 all-match Deoxycytidine kinase NAs.003892 Kcat/Km = 1.2e-05 /uM/s Ratio of Kcat to Km for human dCK expressed in HepG2 cells CHEMBL1142170
NAs.003892 0 all-match Deoxycytidine kinase NAs.003892 Kcat = 0.011 /s Activity of human dCK expressed in HepG2 cells assessed as phosphorylation by coupled enzyme assay CHEMBL1142170
NAs.003894 0 all-match Deoxycytidine kinase NAs.003894 Kcat/Km = 1.5 10'-3/microM/s Ratio of Kcat/Km for human recombinant deoxycytidine kinase CHEMBL1208712
NAs.003894 0 all-match Deoxycytidine kinase NAs.003894 Kcat = 0.1221 /s Activity at human recombinant deoxycytidine kinase expressed in HepG2 cells CHEMBL1208712
NAs.003894 0 all-match Deoxycytidine kinase NAs.003894 Km = 81100.0 nM Activity at human recombinant deoxycytidine kinase expressed in HepG2 cells CHEMBL1208712
NAs.003897 0 all-match Deoxycytidine kinase NAs.003897 Kcat/Km = 2.2 10'-3/microM/s Ratio of Kcat/Km for human recombinant deoxycytidine kinase CHEMBL1208712