NA-DB

显示 1 到 50 条，共 2303 条数据每页数据量:

First <<
Prev <
1
2
3
4
5
6
7
8
9
10
Next >
Last >>

Compound ID	Cluster 0 1 2 3 4 5 6 7 8 9	Compound Type ALL-match base match ribose match	Target Name	Img	Activity				Assay Description	Source
Compound ID	Cluster 0 1 2 3 4 5 6 7 8 9	Compound Type ALL-match base match ribose match	Target Name	Img	Type Ki EC25 Affinity constant pka MPR Displacement Activity K Ratio EC50 Emax IC50 Stimulation Inhibition A2 selectivity Ratio Ki Kb Selectivity Loss Kd Selectivity ratio	Relation = > None <	Value	Unit nM uM None % M g-1 M-1	Assay Description	Source
NAs.000000	2	ribose-match	Adenosine A2 receptor		Ki	=	280.0	nM	Inhibition of binding of [3H]NECA to adenosine A2 receptor of rat striatal membranes.	CHEMBL1124694
NAs.000000	2	ribose-match	Adenosine A2 receptor		Ki	=	350.0	nM	Binding of Adenosine A2 receptor in whole rat brain membrane using [3H]CHA as a Radioligand	CHEMBL1125020
NAs.000000	2	ribose-match	Adenosine A2 receptor		Ki	=	280.0	nM	Binding affinity to A2 adenosine receptor in rat striatal membranes by [3H]NECA (1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide) displacement.	CHEMBL1123600
NAs.000000	2	ribose-match	Adenosine A2 receptor		Ki	=	280.0	nM	Binding affinity towards adenosine A2 receptor on rat striatal membrane using [3H]NECA as radioligand	CHEMBL1124304
NAs.000000	2	ribose-match	Adenosine A2 receptor		EC25	=	35.0	nM	Enhancement of coronary flow (A2 response) in isolated rat heart preparation	CHEMBL1124304
NAs.000000	2	ribose-match	Adenosine A2 receptor		Affinity constant	=	80.0	uM	Affinity constant for A2 receptor control of adenylate cyclase in adipocytes, heart and brain cells	CHEMBL1122012
NAs.000000	2	ribose-match	Adenosine A2 receptor		pka	=	3.07	None	Acidic dissociation constant(pKa) against A2 adenosine receptor of coronary artery	CHEMBL1123294
NAs.000000	2	ribose-match	Adenosine A2 receptor		MPR	=	0.52	None	Molar potency ratio (MPR) against adenosine A2 receptor of canine coronary artery	CHEMBL1123294
NAs.000005	2	ribose-match	Adenosine A2 receptor		Ki	=	182.0	nM	Binding affinity for adenosine A2 receptor in vitro using rat striatal membrane.	CHEMBL1127433
NAs.000005	2	ribose-match	Adenosine A2 receptor		Displacement	=	46.0	%	Percent displacement from adenosine A2 receptor at 10e-7 M in rat striatal membrane in vitro.	CHEMBL1127433
NAs.000005	2	ribose-match	Adenosine A2 receptor		Displacement	=	99.0	%	Percent displacement from adenosine A2 receptor at 10e-5 M in rat striatal membrane in vitro.	CHEMBL1127433
NAs.000010	2	ribose-match	Adenosine A2 receptor		Activity	=	7.3	M g-1	Binding affinity against A2 adenosine receptor	CHEMBL1123294
NAs.000010	2	ribose-match	Adenosine A2 receptor		K	=	19855.0	M-1	Association constant against A2 adenosine receptor	CHEMBL1123294
NAs.000025	2	ribose-match	Adenosine A2 receptor		MPR	=	0.5	None	Molar potency ratio (MPR) against adenosine A2 receptor of canine coronary artery	CHEMBL1123294
NAs.000035	2	ribose-match	Adenosine A2 receptor		MPR	=	1.8	None	Molar potency ratio (MPR) against adenosine A2 receptor of canine coronary artery	CHEMBL1123294
NAs.000041	2	all-match	Adenosine A2 receptor		Ki	=	6.1	nM	Binding affinity against adenosine A2 receptor from rat striatum using [3H]NECA as radioligand.	CHEMBL1125505
NAs.000041	2	all-match	Adenosine A2 receptor		Ki	=	12.1	nM	Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand	CHEMBL1126140
NAs.000041	2	all-match	Adenosine A2 receptor		Ki	=	7.9	nM	Inhibition of [3H]NECA binding to adenosine A2 receptor from rat striatal membranes	CHEMBL1126082
NAs.000041	2	all-match	Adenosine A2 receptor		Ratio	=	12.0	nM	Binding affinity against adenosine A2 receptor using [3H]- NECA as radioligand	CHEMBL1125572
NAs.000041	2	all-match	Adenosine A2 receptor		Ki	=	39.9	nM	Binding affinity against adenosine A2 receptor from human platelet membranes using [3H]NECA	CHEMBL1126089
NAs.000041	2	all-match	Adenosine A2 receptor		EC50	=	681.0	nM	Maximal NECA stimulation of adenylate cyclase via adenosine A2 receptor in human platelet membranes	CHEMBL1126089
NAs.000041	2	all-match	Adenosine A2 receptor		Ki	=	6.3	nM	Binding affinity against adenosine A2 receptor from rat striatal membranes with 50 nM CPA using [3H]-NECA	CHEMBL1126089
NAs.000041	2	all-match	Adenosine A2 receptor		Emax	=	65.0	%	Agonistic activity at adenosine A2 receptor	CHEMBL1126089
NAs.000056	2	all-match	Adenosine A2 receptor		Affinity constant	=	10.0	uM	Affinity constant for A2 receptor control of adenylate cyclase in adipocytes, heart and brain cells	CHEMBL1122012
NAs.000062	2	all-match	Adenosine A2 receptor		Ki	=	5.2	nM	Binding affinity against adenosine A2 receptor from rat striatum using [3H]NECA as radioligand.	CHEMBL1125505
NAs.000064	2	ribose-match	Adenosine A2 receptor		IC50	=	78.0	nM	Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptor	CHEMBL1125861
NAs.000072	2	all-match	Adenosine A2 receptor		Ki	=	2.8	nM	Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand	CHEMBL1126140
NAs.000072	2	all-match	Adenosine A2 receptor		Ki	=	3.6	nM	Binding affinity against adenosine A2 receptor from rat striatal membranes with 50 nM CPA using [3H]-NECA	CHEMBL1126089
NAs.000072	2	all-match	Adenosine A2 receptor		Ki	=	8.1	nM	Binding affinity against adenosine A2 receptor from human platelet membranes using [3H]NECA	CHEMBL1126089
NAs.000072	2	all-match	Adenosine A2 receptor		EC50	=	128.0	nM	Maximal NECA stimulation of adenylate cyclase via adenosine A2 receptor in human platelet membranes	CHEMBL1126089
NAs.000072	2	all-match	Adenosine A2 receptor		Emax	=	65.0	%	Agonistic activity at adenosine A2 receptor	CHEMBL1126089
NAs.000072	2	all-match	Adenosine A2 receptor		Ratio	=	4.1	nM	Binding affinity against adenosine A2 receptor using [3H]- NECA as radioligand	CHEMBL1125572
NAs.000072	2	all-match	Adenosine A2 receptor		Ki	=	2.8	nM	Inhibition of [3H]NECA binding to adenosine A2 receptor from rat striatal membranes	CHEMBL1126082
NAs.000072	2	all-match	Adenosine A2 receptor		Ki	=	2.4	nM	Binding affinity against adenosine A2 receptor from rat striatum using [3H]NECA as radioligand.	CHEMBL1125505
NAs.000073	2	ribose-match	Adenosine A2 receptor		Ki	=	1.9	nM	Inhibition of [3H]NECA binding to adenosine A2 receptor from rat striatal membranes	CHEMBL1126082
NAs.000081	2	ribose-match	Adenosine A2 receptor		MPR	=	0.48	None	Molar potency ratio (MPR) against adenosine A2 receptor of canine coronary artery	CHEMBL1123294
NAs.000087	2	ribose-match	Adenosine A2 receptor		Displacement	=	76.0	%	Percent displacement from adenosine A2 receptor at 10e-5 M in rat striatal membrane in vitro.	CHEMBL1127433
NAs.000087	2	ribose-match	Adenosine A2 receptor		Displacement	=	8.0	%	Percent displacement from adenosine A2 receptor at 10e-7 M in rat striatal membrane in vitro.	CHEMBL1127433
NAs.000087	2	ribose-match	Adenosine A2 receptor		Ki	=	1400.0	nM	Binding affinity for adenosine A2 receptor in vitro using rat striatal membrane.	CHEMBL1127433
NAs.000088	2	all-match	Adenosine A2 receptor		EC50	=	1200.0	nM	Potency against PC12 cell A2 adenosine receptor by adenylate cyclase activation	CHEMBL1123491
NAs.000088	2	all-match	Adenosine A2 receptor		EC50	=	4400.0	nM	Potency against human platelet A2 adenosine receptor	CHEMBL1123491
NAs.000091	2	ribose-match	Adenosine A2 receptor		EC50	=	12.59	nM	Tested for adenosine A2 receptor agonistic activity by determining coronary vasodilation	CHEMBL1126102
NAs.000092	2	all-match	Adenosine A2 receptor		EC50	=	69.3	nM	Negative chronotropic activity via A2 Adenosine receptor was tested monitoring vasodilation in rat aorta	CHEMBL1127534
NAs.000092	2	all-match	Adenosine A2 receptor		Ki	=	12.4	nM	Affinity for A2 Adenosine receptor in rat striatum using [3H]-CGS- 21680	CHEMBL1127534
NAs.000094	2	ribose-match	Adenosine A2 receptor		Ki	=	175.0	nM	Binding affinity towards adenosine A2 receptor	CHEMBL1125617
NAs.000101	2	all-match	Adenosine A2 receptor		Ratio	=	22.0	nM	Binding affinity against adenosine A2 receptor using [3H]- NECA as radioligand	CHEMBL1125572
NAs.000101	2	all-match	Adenosine A2 receptor		EC50	=	1.023	nM	Coronary arteries vasodilation at the adenosine A2 receptor in langendorff guinea pig heart preparation	CHEMBL1125661
NAs.000111	2	all-match	Adenosine A2 receptor		Ki	=	11500.0	nM	Displacement of [3H]-CGS- 21680 from Adenosine A2 receptor of rat striatal membranes	CHEMBL1129060
NAs.000121	2	ribose-match	Adenosine A2 receptor		EC50	=	1.585	nM	Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation	CHEMBL1125902
NAs.000124	2	all-match	Adenosine A2 receptor		Ki	=	3400.0	nM	Tested for inhibition of rat PC12 adenylate cyclase stimulation by using NECA as a radioligand	CHEMBL1125213