| Compound ID |
Cluster
|
Compound Type
|
Target Name | Img | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000797 | 2 | all-match | Brain adenylate cyclase 1 |  |
Activity | = | 46.0 | % | Inhibition of human AC1 expressed in HEK293 cells assessed as remaining activity by measuring cAMP level at 30 uM relative to control | CHEMBL4823269 | |
| NAs.002909 | 2 | all-match | Brain adenylate cyclase 1 |  |
IC50 | = | 10000.0 | nM | Inhibition of AC1 (unknown origin) expressed in HEK293 cells assessed as decrease in Ca2+/calmodulin-mediated cAMP accumulation by enzyme immunoassay | CHEMBL4382248 | |
| NAs.006225 | 7 | ribose-match | Brain adenylate cyclase 1 |  |
Ki | > | 5000.0 | nM | KB for inhibition of adenylate cyclase stimulation in human platelet membranes | CHEMBL1126169 | |
| NAs.007181 | 7 | all-match | Brain adenylate cyclase 1 |  |
Kb | = | 220.0 | nM | Inhibition of adenylate cyclase stimulation by N-[3H]-ethyladenosin-5''-uronamide in human platelet membranes. | CHEMBL1126087 | |
| NAs.007602 | 7 | all-match | Brain adenylate cyclase 1 |  |
Kb | = | 30000.0 | nM | Inhibition of adenylate cyclase stimulation by N-[3H]-ethyladenosin-5''-uronamide in human platelet membranes | CHEMBL1126087 | |
| NAs.008636 | 7 | base-match | Brain adenylate cyclase 1 |  |
Activity | = | 64.0 | % | Inhibition of human AC1 expressed in HEK293 cells assessed as remaining activity by measuring cAMP level at 30 uM relative to control | CHEMBL4823269 | |