| Compound ID |
Cluster
|
Compound Type
|
Target Name | Img | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 3A |  |
IC50 | > | 50000.0 | nM | Inhibition of human full length DNMT3A expressed in Sf9 cells | CHEMBL3576805 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 3A | |
Inhibition | = | 96.7 | % | Inhibition of recombinant human DNMT3A-3L expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM using Poly(dI-dC)-Poly(dI-dC) as substrate measured at 150 mins by liquid scintillation counting analysis | CHEMBL5131574 | |
| NAs.000947 | 2 | all-match | DNA (cytosine-5)-methyltransferase 3A |  |
Inhibition | = | 98.0 | % | Inhibition of recombinant human DNMT3A-3L expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM using Poly(dI-dC)-Poly(dI-dC) as substrate measured at 150 mins by liquid scintillation counting analysis | CHEMBL5131574 | |
| NAs.002202 | 7 | all-match | DNA (cytosine-5)-methyltransferase 3A |  |
Inhibition | None | None | % | Inhibition of human C-terminal DNMT3A at 20 uM after 1 hr by fluorescence assay | CHEMBL3603802 | |
| NAs.002202 | 7 | all-match | DNA (cytosine-5)-methyltransferase 3A | |
Inhibition | = | 54.0 | % | Inhibition of human C-terminal DNMT3A at 32 uM after 1 hr by fluorescence assay | CHEMBL3603802 | |
| NAs.002306 | 2 | all-match | DNA (cytosine-5)-methyltransferase 3A |  |
IC50 | > | 50000.0 | nM | Inhibition of human full length DNMT3A expressed in Sf9 cells | CHEMBL3576805 | |
| NAs.002977 | 7 | all-match | DNA (cytosine-5)-methyltransferase 3A |  |
Inhibition | None | None | % | Inhibition of human C-terminal DNMT3A at 20 uM after 1 hr by fluorescence assay | CHEMBL3603802 | |
| NAs.002977 | 7 | all-match | DNA (cytosine-5)-methyltransferase 3A | |
EC50 | = | 2100.0 | nM | Inhibition of human C-terminal DNMT3A after 1 hr by fluorescence assay | CHEMBL3603802 | |
| NAs.002977 | 7 | all-match | DNA (cytosine-5)-methyltransferase 3A | |
Inhibition | = | 70.0 | % | Inhibition of human C-terminal DNMT3A at 32 uM after 1 hr by fluorescence assay | CHEMBL3603802 | |
| NAs.003098 | 2 | all-match | DNA (cytosine-5)-methyltransferase 3A |  |
Inhibition | = | 97.6 | % | Inhibition of recombinant human DNMT3A-3L expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM using Poly(dI-dC)-Poly(dI-dC) as substrate measured at 150 mins by liquid scintillation counting analysis | CHEMBL5131574 | |
| NAs.004047 | 2 | all-match | DNA (cytosine-5)-methyltransferase 3A |  |
Inhibition | = | 0.0 | % | Inhibition of human C-terminal DNMT3A at 32 uM after 1 hr by fluorescence assay | CHEMBL3603802 | |
| NAs.004047 | 2 | all-match | DNA (cytosine-5)-methyltransferase 3A | |
Inhibition | None | None | % | Inhibition of human C-terminal DNMT3A at 20 uM after 1 hr by fluorescence assay | CHEMBL3603802 | |
| NAs.004083 | 7 | base-match | DNA (cytosine-5)-methyltransferase 3A |  |
Inhibition | = | 44.0 | % | Inhibition of human DNMT3A catalytic domain using AdoMet assessed as reduction of methylation in 5'-biotin/3' 6-carboxyfluorescein labeled DNA duplex at CpG site at 32 uM after 1 hr by fluorescence assay relative to control | CHEMBL4014314 | |
| NAs.004083 | 7 | base-match | DNA (cytosine-5)-methyltransferase 3A | |
Inhibition | = | 10.0 | % | Inhibition of human DNMT3A catalytic domain using AdoMet assessed as reduction of methylation in 5'-biotin/3' 6-carboxyfluorescein labeled DNA duplex at CpG site at 10 uM after 1 hr by fluorescence assay relative to control | CHEMBL4014314 | |
| NAs.004225 | 7 | base-match | DNA (cytosine-5)-methyltransferase 3A |  |
Inhibition | = | 0.0 | % | Inhibition of human DNMT3A catalytic domain using AdoMet assessed as reduction of methylation in 5'-biotin/3' 6-carboxyfluorescein labeled DNA duplex at CpG site at 32 uM after 1 hr by fluorescence assay relative to control | CHEMBL4014314 | |
| NAs.004225 | 7 | base-match | DNA (cytosine-5)-methyltransferase 3A | |
Inhibition | = | 0.0 | % | Inhibition of human DNMT3A catalytic domain using AdoMet assessed as reduction of methylation in 5'-biotin/3' 6-carboxyfluorescein labeled DNA duplex at CpG site at 10 uM after 1 hr by fluorescence assay relative to control | CHEMBL4014314 | |
| NAs.008389 | 2 | all-match | DNA (cytosine-5)-methyltransferase 3A |  |
IC50 | = | 7600.0 | nM | Inhibition of human DNMT3a expressed in insect sf9 cells assessed as reduction in methylated poly(dI-dC)-Poly(dI-dC) level using poly(dI-dC)-poly(dI-dC) as substrate in presence of [3H] SAM incubated for 10 mins by scintillation counting | CHEMBL4414609 | |
| NAs.008735 | 7 | base-match | DNA (cytosine-5)-methyltransferase 3A |  |
Inhibition | None | None | % | Inhibition of DNMT3A (unknown origin) at 500 uM | CHEMBL4330181 | |
| NAs.008932 | 2 | all-match | DNA (cytosine-5)-methyltransferase 3A |  |
Inhibition | = | 84.2 | % | Inhibition of recombinant human DNMT3A-3L expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM using Poly(dI-dC)-Poly(dI-dC) as substrate measured at 150 mins by liquid scintillation counting analysis | CHEMBL5131574 | |
| NAs.008945 | 2 | all-match | DNA (cytosine-5)-methyltransferase 3A |  |
Inhibition | = | 93.9 | % | Inhibition of recombinant human DNMT3A-3L expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM using Poly(dI-dC)-Poly(dI-dC) as substrate measured at 150 mins by liquid scintillation counting analysis | CHEMBL5131574 | |
| NAs.008946 | 2 | all-match | DNA (cytosine-5)-methyltransferase 3A |  |
Inhibition | = | 95.3 | % | Inhibition of recombinant human DNMT3A-3L expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM using Poly(dI-dC)-Poly(dI-dC) as substrate measured at 150 mins by liquid scintillation counting analysis | CHEMBL5131574 | |