| Compound ID |
Cluster
|
Compound Type
|
Target Name | Img | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000002 | 7 | all-match | DNA polymerase beta |  |
Potency | = | 100000.0 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000033 | 2 | all-match | Human herpesvirus 1 DNA polymerase |  |
MP | = | 0.0 | % | Percentage of monophosphates (MP) formed in the first step of staggered assay compound was incubated with HSV-1 thymidine kinase for 4 hr | CHEMBL1124020 | |
| NAs.000033 | 2 | all-match | Human herpesvirus 1 DNA polymerase | |
MP | = | 0.0 | % | Percentage of monophosphates (MP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night | CHEMBL1124020 | |
| NAs.000033 | 2 | all-match | Human herpesvirus 1 DNA polymerase | |
DP | = | 0.0 | % | Percentage of diphosphates (DP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night | CHEMBL1124020 | |
| NAs.000033 | 2 | all-match | Human herpesvirus 1 DNA polymerase | |
TP | = | 0.0 | % | Percentage of triphosphates (TP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night | CHEMBL1124020 | |
| NAs.000033 | 2 | all-match | Human herpesvirus 1 DNA polymerase | |
Inhibition | = | 0.0 | % | Inhibition of DNA polymerase | CHEMBL1124020 | |
| NAs.000080 | 7 | all-match | DNA polymerase iota |  |
Potency | None | 89125.1 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.000113 | 2 | all-match | DNA polymerase gamma subunit 1 |  |
Activity | = | 100.0 | uM | Inhibition of human recombinant DNA polymerase gamma by scintillation counting | CHEMBL1157759 | |
| NAs.000120 | 2 | all-match | DNA polymerase beta |  |
Potency | = | 79432.8 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000218 | 7 | ribose-match | DNA polymerase beta |  |
Potency | = | 79432.8 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000223 | 7 | all-match | DNA polymerase beta |  |
IC50 | = | 23000.0 | nM | Inhibition of human DNA polymerase beta by microplate reader analysis | CHEMBL1649500 | |
| NAs.000223 | 7 | all-match | DNA polymerase gamma subunit 1 | |
IC50 | > | 150000.0 | nM | Inhibition of human DNA polymerase gamma by microplate reader analysis | CHEMBL1649500 | |
| NAs.000223 | 7 | all-match | DNA polymerase alpha subunit | |
IC50 | > | 100000.0 | nM | Inhibition of human DNA polymerase alpha by microplate reader analysis | CHEMBL1649500 | |
| NAs.000304 | 2 | ribose-match | DNA polymerase iota |  |
Potency | None | 63095.7 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.000318 | 7 | ribose-match | DNA polymerase kappa |  |
Potency | None | 21192.3 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | CHEMBL1201862 | |
| NAs.000403 | 2 | all-match | DNA polymerase iota |  |
Potency | None | 25118.9 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.000469 | 7 | ribose-match | DNA polymerase beta |  |
Potency | = | 100000.0 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000534 | 2 | all-match | DNA polymerase eta |  |
Potency | None | 281.8 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | CHEMBL1201862 | |
| NAs.000635 | 7 | base-match | DNA polymerase eta |  |
Potency | None | 89125.1 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | CHEMBL1201862 | |
| NAs.000651 | 2 | ribose-match | DNA polymerase iota |  |
Potency | None | 89125.1 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.000670 | 2 | ribose-match | DNA polymerase beta |  |
Potency | = | 89125.1 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000877 | 7 | ribose-match | DNA polymerase beta |  |
Potency | = | 79432.8 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000885 | 7 | ribose-match | DNA polymerase beta |  |
Potency | = | 100000.0 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000926 | 7 | ribose-match | DNA polymerase iota |  |
Potency | None | 79432.8 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.000926 | 7 | ribose-match | DNA polymerase beta | |
Potency | = | 25118.9 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.000935 | 2 | ribose-match | DNA polymerase iota |  |
Potency | None | 79432.8 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.000938 | 2 | ribose-match | DNA polymerase kappa |  |
Potency | None | 33587.5 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | CHEMBL1201862 | |
| NAs.001024 | 7 | ribose-match | DNA polymerase beta |  |
Potency | = | 100000.0 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.001024 | 7 | ribose-match | DNA polymerase iota | |
Potency | None | 56234.1 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.001421 | 7 | base-match | DNA polymerase alpha subunit |  |
Ki | = | 14400.0 | nM | Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha | CHEMBL1123655 | |
| NAs.001497 | 2 | all-match | DNA polymerase iota |  |
Potency | None | 3.5 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.001547 | 7 | ribose-match | DNA polymerase beta |  |
Potency | = | 3548.1 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.001547 | 7 | ribose-match | DNA polymerase iota | |
Potency | None | 2238.7 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.001547 | 7 | ribose-match | DNA polymerase eta | |
Potency | None | 3162.3 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | CHEMBL1201862 | |
| NAs.001547 | 7 | ribose-match | DNA polymerase kappa | |
Potency | None | 15848.9 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | CHEMBL1201862 | |
| NAs.001547 | 7 | ribose-match | DNA polymerase eta | |
Potency | None | 47754.8 | nM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.001552 | 7 | ribose-match | DNA polymerase beta |  |
Potency | = | 79432.8 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.001552 | 7 | ribose-match | DNA polymerase iota | |
Potency | None | 79432.8 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.001558 | 2 | all-match | Human herpesvirus 1 DNA polymerase |  |
Inhibition | = | 0.0 | % | Inhibition of DNA polymerase | CHEMBL1124020 | |
| NAs.001558 | 2 | all-match | Human herpesvirus 1 DNA polymerase | |
TP | = | 0.0 | % | Percentage of triphosphates (TP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night | CHEMBL1124020 | |
| NAs.001558 | 2 | all-match | Human herpesvirus 1 DNA polymerase | |
DP | = | 0.0 | % | Percentage of diphosphates (DP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night | CHEMBL1124020 | |
| NAs.001558 | 2 | all-match | Human herpesvirus 1 DNA polymerase | |
MP | = | 0.0 | % | Percentage of monophosphates (MP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night | CHEMBL1124020 | |
| NAs.001704 | 2 | all-match | Human herpesvirus 1 DNA polymerase |  |
MP | = | 0.0 | % | Percentage of monophosphates (MP) formed in the first step of staggered assay compound was incubated with HSV-1 thymidine kinase for 4 hr | CHEMBL1124020 | |
| NAs.001704 | 2 | all-match | Human herpesvirus 1 DNA polymerase | |
MP | = | 0.0 | % | Percentage of monophosphates (MP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night | CHEMBL1124020 | |
| NAs.001704 | 2 | all-match | Human herpesvirus 1 DNA polymerase | |
DP | = | 0.0 | % | Percentage of diphosphates (DP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night | CHEMBL1124020 | |
| NAs.001704 | 2 | all-match | Human herpesvirus 1 DNA polymerase | |
TP | = | 0.0 | % | Percentage of triphosphates (TP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night | CHEMBL1124020 | |
| NAs.001704 | 2 | all-match | Human herpesvirus 1 DNA polymerase | |
Inhibition | = | 0.0 | % | Inhibition of DNA polymerase | CHEMBL1124020 | |
| NAs.001708 | 7 | all-match | DNA polymerase iota |  |
Potency | None | 28183.8 | nM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | CHEMBL1201862 | |
| NAs.001769 | 7 | ribose-match | DNA polymerase beta |  |
Potency | = | 100000.0 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |
| NAs.001785 | 7 | ribose-match | DNA polymerase beta |  |
Potency | = | 891.3 | nM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | CHEMBL1201862 | |