显示 1 到 50 条，共 69 条数据 每页数据量:
Compound ID
Cluster
Compound Type
Target Name Img Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000223 7 all-match DNA polymerase alpha subunit NAs.000223 IC50 > 100000.0 nM Inhibition of human DNA polymerase alpha by microplate reader analysis CHEMBL1649500
NAs.001421 7 base-match DNA polymerase alpha subunit NAs.001421 Ki = 14400.0 nM Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha CHEMBL1123655
NAs.002329 0 all-match DNA polymerase alpha subunit NAs.002329 Km = 4.0 None Km value with DNA polymerase alpha CHEMBL1135827
NAs.002403 0 all-match DNA polymerase alpha subunit NAs.002403 Ki = 548000.0 nM Ability to inhibit the incorporation of dATP into DNA by DNA polymerase alpha CHEMBL1135827
NAs.002857 7 all-match DNA polymerase alpha subunit NAs.002857 IC50 > 100000.0 nM Inhibition of human DNA polymerase alpha by microplate reader analysis CHEMBL1649500
NAs.003192 0 all-match DNA polymerase alpha subunit NAs.003192 EC50 = 70000.0 nM Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs CHEMBL3232882
NAs.003597 0 all-match DNA polymerase alpha subunit NAs.003597 IC50 > 200000.0 nM Inhibition of recombinant human DNA polymerase alpha preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamma-33P]TTP by phosphorimaging assay CHEMBL4007399
NAs.003743 7 all-match DNA polymerase alpha subunit NAs.003743 Inhibition = 0.0 % Compound was tested for the inhibition of HeLa DNA polymerase CHEMBL1123186
NAs.003744 7 all-match DNA polymerase alpha subunit NAs.003744 Inhibition = 10.0 % Compound was tested for the inhibition of HeLa DNA polymerase CHEMBL1123186
NAs.003764 7 all-match DNA polymerase alpha subunit NAs.003764 Inhibition = 6.0 % Compound was tested for the inhibition of HeLa DNA polymerase CHEMBL1123186
NAs.003788 0 all-match DNA polymerase alpha subunit NAs.003788 Ki = 156000.0 nM Ability to inhibit the incorporation of dATP into DNA by DNA polymerase alpha CHEMBL1135827
NAs.004095 0 all-match DNA polymerase alpha subunit NAs.004095 EC50 = 410000.0 nM Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs CHEMBL3232882
NAs.004123 0 all-match DNA polymerase alpha subunit NAs.004123 EC50 > 500000.0 nM Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs CHEMBL3232882
NAs.004131 0 all-match DNA polymerase alpha subunit NAs.004131 EC50 > 500000.0 nM Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs CHEMBL3232882
NAs.004135 0 all-match DNA polymerase alpha subunit NAs.004135 EC50 = 350000.0 nM Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs CHEMBL3232882
NAs.004140 0 all-match DNA polymerase alpha subunit NAs.004140 EC50 > 500000.0 nM Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs CHEMBL3232882
NAs.004145 0 all-match DNA polymerase alpha subunit NAs.004145 IC50 > 200000.0 nM Compound was evaluated for the inhibition of cellular DNA polymerase (alpha) CHEMBL1131623
NAs.004145 0 all-match DNA polymerase alpha subunit NAs.004145 IC50 = 800.0 nM Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus) CHEMBL1131623
NAs.004145 0 all-match DNA polymerase alpha subunit NAs.004145 IC50 = 10400.0 nM Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus) CHEMBL1131623
NAs.004145 0 all-match DNA polymerase alpha subunit NAs.004145 IC50 > 100000.0 nM Compound was evaluated for the inhibition of cellular DNA polymerase (alpha) CHEMBL1131623
NAs.004154 0 all-match DNA polymerase alpha subunit NAs.004154 EC50 = 250000.0 nM Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs CHEMBL3232882
NAs.004199 0 all-match DNA polymerase alpha subunit NAs.004199 EC50 > 500000.0 nM Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs CHEMBL3232882
NAs.004202 0 all-match DNA polymerase alpha subunit NAs.004202 EC50 > 500000.0 nM Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs CHEMBL3232882
NAs.004216 0 all-match DNA polymerase alpha subunit NAs.004216 IC50 = 15.0 nM Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus) CHEMBL1131623
NAs.004216 0 all-match DNA polymerase alpha subunit NAs.004216 IC50 > 200000.0 nM Compound was evaluated for the inhibition of cellular DNA polymerase (alpha) CHEMBL1131623
NAs.004216 0 all-match DNA polymerase alpha subunit NAs.004216 IC50 = 2000.0 nM Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus) CHEMBL1131623
NAs.004216 0 all-match DNA polymerase alpha subunit NAs.004216 IC50 > 200000.0 nM Compound was evaluated for the inhibition of cellular DNA polymerase (alpha) CHEMBL1131623
NAs.004281 0 all-match DNA polymerase alpha subunit NAs.004281 EC50 = 80000.0 nM Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs CHEMBL3232882
NAs.004281 0 all-match DNA polymerase alpha subunit NAs.004281 Inhibition None None % Competitive inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction by dose response curve assay CHEMBL3232882
NAs.004311 0 all-match DNA polymerase alpha subunit NAs.004311 IC50 = 1000.0 nM Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus) CHEMBL1131623
NAs.004311 0 all-match DNA polymerase alpha subunit NAs.004311 IC50 > 100000.0 nM Compound was evaluated for the inhibition of cellular DNA polymerase (alpha) CHEMBL1131623
NAs.004325 0 ribose-match DNA polymerase alpha subunit NAs.004325 Ki = 22000.0 nM Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTP CHEMBL1122564
NAs.004325 0 ribose-match DNA polymerase alpha subunit NAs.004325 Ki = 37000.0 nM Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTP CHEMBL1122564
NAs.004325 0 ribose-match DNA polymerase alpha subunit NAs.004325 Ki = 2300.0 nM Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTP CHEMBL1122564
NAs.004343 0 all-match DNA polymerase alpha subunit NAs.004343 Inhibition = 78.7 % Inhibition of human DNA polymerase alpha at 100 uM using calf DNA as substrate by microbeta scintillation counting method relative to control CHEMBL4622986
NAs.004349 7 all-match DNA polymerase alpha subunit NAs.004349 IC50 None None nM Compound was evaluated for the inhibitory activity against Human alpha polymerase; No data CHEMBL1133310
NAs.004349 7 all-match DNA polymerase alpha subunit NAs.004349 Inhibition = 17.0 % Compound was tested for the inhibition of HeLa DNA polymerase CHEMBL1123186
NAs.004356 7 all-match DNA polymerase alpha subunit NAs.004356 Inhibition = 37.0 % Compound was tested for the inhibition of HeLa DNA polymerase CHEMBL1123186
NAs.004397 0 all-match DNA polymerase alpha subunit NAs.004397 IC50 > 500000.0 nM Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding assay CHEMBL1629705
NAs.004415 0 all-match DNA polymerase alpha subunit NAs.004415 Inhibition = 3.6 % Inhibition of human DNA polymerase alpha at 100 uM using calf DNA as substrate by microbeta scintillation counting method relative to control CHEMBL4622986
NAs.004419 0 all-match DNA polymerase alpha subunit NAs.004419 IC50 > 40000.0 nM Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus) CHEMBL1131623
NAs.004419 0 all-match DNA polymerase alpha subunit NAs.004419 IC50 > 100000.0 nM Compound was evaluated for the inhibition of cellular DNA polymerase (alpha) CHEMBL1131623
NAs.004419 0 all-match DNA polymerase alpha subunit NAs.004419 IC50 > 40000.0 nM Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus) CHEMBL1131623
NAs.004419 0 all-match DNA polymerase alpha subunit NAs.004419 IC50 > 200000.0 nM Compound was evaluated for the inhibition of cellular DNA polymerase (alpha) CHEMBL1131623
NAs.004422 0 all-match DNA polymerase alpha subunit NAs.004422 Inhibition = 22.4 % Inhibition of human DNA polymerase-alpha assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 100 uM by scintillation counting method relative to control CHEMBL4393666
NAs.004450 0 all-match DNA polymerase alpha subunit NAs.004450 IC50 = 550000.0 nM Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding assay CHEMBL1629705
NAs.004450 0 all-match DNA polymerase alpha subunit NAs.004450 IC50 > 100000.0 nM Inhibition of human DNA polymerase alpha using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysis CHEMBL4014354
NAs.004450 0 all-match DNA polymerase alpha subunit NAs.004450 Inhibition = 58.2 % Inhibition of human DNA polymerase-alpha assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 100 uM by scintillation counting method relative to control CHEMBL4393666
NAs.004450 0 all-match DNA polymerase alpha subunit NAs.004450 IC50 > 100000.0 nM Inhibition of human DNA polymerase alpha using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP by PAGE analysis CHEMBL4411318
NAs.004470 0 all-match DNA polymerase alpha subunit NAs.004470 Inhibition = 34.5 % Inhibition of human DNA polymerase-alpha assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 100 uM by scintillation counting method relative to control CHEMBL4393666