显示 1 到 50 条，共 119 条数据 每页数据量:
Compound ID
Cluster
Compound Type
Target Name Img Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000102 2 all-match NS5 NAs.000102 EC50 None None None Inhibition of RNA-dependent RNA polymerase in ZIKV SL0612 infected in African green monkey Vero cells assessed as reduction in virus-induced cytopathic effect measured after 96 hrs post-infection by MTS assay CHEMBL4359835
NAs.000191 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.000191 IC50 = 47000.0 nM Inhibition HCV NS5B-mediated RNA synthesis CHEMBL1149159
NAs.000191 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.000191 EC50 > 50000.0 nM Inhibition HCV RNA replication CHEMBL1149159
NAs.000213 2 all-match NS5 NAs.000213 Kd = 2580.0 nM Binding affinity to Zika virus Methyltransferase CHEMBL4354808
NAs.000214 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.000214 Ki/Km = 84.0 None Ratio of Ki to Km for HCV NS5B RNA polymerase S282T mutant CHEMBL1142170
NAs.000214 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.000214 IC50 > 100000.0 nM Inhibition of HCV NS5B polymerase S282T mutant assessed as blocking of full length RNA product formation by single-nucleotide incorporation assay CHEMBL1155141
NAs.000214 2 all-match NS5 NAs.000214 IC50 = 5260.0 nM Inhibition of Zika virus RNA-dependent RNA polymerase activity CHEMBL5150000
NAs.000250 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.000250 IC50 > 50000.0 nM Inhibition HCV NS5B-mediated RNA synthesis CHEMBL1149159
NAs.000250 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.000250 EC50 > 50000.0 nM Inhibition HCV RNA replication CHEMBL1149159
NAs.000627 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.000627 IC50 = 1900.0 nM Inhibition HCV NS5B-mediated RNA synthesis CHEMBL1149159
NAs.000627 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.000627 EC50 = 300.0 nM Inhibition HCV RNA replication CHEMBL1149159
NAs.000947 2 all-match NS5 NAs.000947 IC50 = 1180.0 nM Inhibition of Zika virus MTase (4 to 278 residues) expressed in Escherichia coli T7 using GpppAC4 as substrate in presence of [3H]SAM incubated for 30 mins by liquid scintillation counter method CHEMBL4354808
NAs.000947 2 all-match NS5 NAs.000947 IC50 = 1620.0 nM Inhibition of Zika virus MTase (4 to 278 residues) expressed in Escherichia coli T7 using A27 RNA as substrate in presence of [3H]SAM incubated for 30 mins by liquid scintillation counter method CHEMBL4354808
NAs.002277 2 all-match NS5 NAs.002277 EC50 = 640.0 nM Inhibition of RNA-dependent RNA polymerase in ZIKV SL0612 infected in African green monkey Vero cells assessed as reduction in virus-induced cytopathic effect measured after 96 hrs post-infection by MTS assay CHEMBL4359835
NAs.002453 2 all-match NS5 NAs.002453 EC50 = 2540.0 nM Inhibition of RNA-dependent RNA polymerase in ZIKV SL0612 infected in African green monkey Vero cells assessed as reduction in virus-induced cytopathic effect measured after 96 hrs post-infection by MTS assay CHEMBL4359835
NAs.002894 2 ribose-match NS5 NAs.002894 IC50 = 500.0 nM Inhibition of Zika virus RNA-dependent RNA polymerase CHEMBL5150000
NAs.003295 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.003295 IC50 = 22000.0 nM Inhibition HCV NS5B-mediated RNA synthesis CHEMBL1149159
NAs.003295 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.003295 EC50 None 46000.0 nM Inhibition HCV RNA replication CHEMBL1149159
NAs.003296 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.003296 Km = 133000.0 nM Steady-state kinetic constant for Hepatitis C Virus NS5BRdRp CHEMBL1143599
NAs.003296 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.003296 Vmax = 0.23 uM/min Incorporation efficiency for Hepatitis C Virus NS5BRdRp CHEMBL1143599
NAs.003296 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.003296 Ratio = 1700.0 None Ratio of steady state kinetic constant and incorporation efficiency for Hepatitis C Virus NS5BRdRp CHEMBL1143599
NAs.003296 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.003296 Km = 260.0 nM Activity of HCV NS5B RNA polymerase S282T assessed as incorporation of 32P-UMP into RNA CHEMBL1142170
NAs.003296 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.003296 Kcat = 0.000167 /s Activity of HCV NS5B RNA polymerase S282T assessed as incorporation of 32P-UMP into RNA CHEMBL1142170
NAs.003537 0 all-match NS5 NAs.003537 IC50 = 1360.0 nM Inhibition of Zika virus RNA-dependent RNA polymerase activity CHEMBL5150000
NAs.003614 2 all-match NS5 NAs.003614 EC50 = 20800.0 nM Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity after 72 hrs by DAPI staining based assay CHEMBL4354808
NAs.003654 2 all-match NS5 NAs.003654 EC50 = 1300.0 nM Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by measuring reduction in virus-induced cytopathic effect after 5 days by MTS assay CHEMBL4354808
NAs.003654 2 all-match NS5 NAs.003654 EC50 = 1300.0 nM Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by measuring reduction in virus-yield CHEMBL4354808
NAs.003654 2 all-match NS5 NAs.003654 EC50 = 1300.0 nM Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by methylene blue staining based by Plaque reduction assay CHEMBL4354808
NAs.003654 2 all-match NS5 NAs.003654 EC50 = 1300.0 nM Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by Alexa Fluor 488/DAPI staining based assay CHEMBL4354808
NAs.003773 0 all-match NS5 NAs.003773 IC50 = 8920.0 nM Inhibition of Zika virus RNA-dependent RNA polymerase activity CHEMBL5150000
NAs.003820 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.003820 IC50 = 56700.0 nM Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive assay in presence of [alpha32p]UTP CHEMBL3120143
NAs.003892 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.003892 EC50 = 2800.0 nM Inhibition of NS5B polymerase in wild type HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assay CHEMBL4411318
NAs.003892 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.003892 EC90 = 9.9 uM Inhibition of NS5B polymerase in wild type HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assay CHEMBL4411318
NAs.004077 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004077 Ki/Km = 0.93 None Ratio of Ki to Km for HCV NS5B RNA polymerase S282T mutant CHEMBL1142170
NAs.004077 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004077 Ki = 310.0 nM Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation counting CHEMBL1152990
NAs.004077 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004077 Km = 52.0 nM Activity of HCV NS5B polymerase S282T mutant CHEMBL1152990
NAs.004077 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004077 Ki/Km = 6.0 None Ratio of Ki to Km for HCV NS5B polymerase S282T mutant CHEMBL1152990
NAs.004077 0 all-match NS5 NAs.004077 Inhibition = 67.4 % Inhibition of Zika virus RNA-dependent RNA polymerase relative to control CHEMBL5150000
NAs.004200 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004200 EC50 = 366.0 nM Inhibition of NS5B S282T mutant in HCV genotype 1b replicon expressed in human HuH7 cells after 72 hrs by bright Glo-luciferase reporter gene assay CHEMBL4011639
NAs.004305 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004305 IC50 = 27.0 nM Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template measured after 2 hrs by microscintillation counting method CHEMBL4393666
NAs.004343 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004343 IC50 = 5940.0 nM Inhibition of HCV NS5B polymerase CHEMBL1629430
NAs.004343 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004343 IC50 = 99.0 nM Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into RNA using cIRES template measured after 2 hrs by microscintillation counting method CHEMBL4622986
NAs.004402 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004402 IC50 = 130.0 nM Inhibition HCV NS5B-mediated RNA synthesis CHEMBL1149159
NAs.004402 2 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004402 EC50 None 3500.0 nM Inhibition HCV RNA replication CHEMBL1149159
NAs.004415 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004415 IC50 = 420.0 nM Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into RNA using cIRES template measured after 2 hrs by microscintillation counting method CHEMBL4622986
NAs.004422 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004422 IC50 = 8240.0 nM Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase S282T mutant CHEMBL4043192
NAs.004422 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004422 IC50 = 63.0 nM Inhibition of NS5B polymerase in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis CHEMBL4411318
NAs.004422 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004422 IC50 = 25.0 nM Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis CHEMBL4411318
NAs.004422 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004422 IC50 = 47.0 nM Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis CHEMBL4411318
NAs.004422 0 all-match Hepatitis C virus NS5B RNA-dependent RNA polymerase NAs.004422 IC50 = 47.0 nM Inhibition of NS5B polymerase in HCV genotype 6a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis CHEMBL4411318