| Compound ID |
Cluster
|
Compound Type
|
Target Name | Img | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000023 | 7 | all-match | AMP-activated protein kinase, alpha-2 subunit |  |
Thermal melting change | = | 1.4 | degrees C | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | CHEMBL1145498 | |
| NAs.000283 | 7 | ribose-match | AMP-activated protein kinase, alpha-2 subunit |  |
Thermal melting change | = | 0.6 | degrees C | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | CHEMBL1145498 | |
| NAs.000995 | 7 | ribose-match | AMP-activated protein kinase, alpha-2 subunit |  |
Thermal melting change | = | 0.2 | degrees C | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | CHEMBL1145498 | |
| NAs.001019 | 7 | ribose-match | AMP-activated protein kinase, alpha-2 subunit |  |
Thermal melting change | = | 0.3 | degrees C | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | CHEMBL1145498 | |
| NAs.001156 | 7 | ribose-match | AMP-activated protein kinase, alpha-2 subunit |  |
Thermal melting change | = | 0.2 | degrees C | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | CHEMBL1145498 | |
| NAs.001163 | 7 | base-match | AMP-activated protein kinase, alpha-2 subunit |  |
Thermal melting change | = | -0.6 | degrees C | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | CHEMBL1145498 | |
| NAs.001310 | 7 | ribose-match | AMP-activated protein kinase, alpha-2 subunit |  |
Thermal melting change | = | -0.7 | degrees C | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | CHEMBL1145498 | |
| NAs.001420 | 7 | ribose-match | AMP-activated protein kinase, alpha-2 subunit |  |
Thermal melting change | = | 0.2 | degrees C | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | CHEMBL1145498 | |
| NAs.001541 | 7 | all-match | AMP-activated protein kinase, alpha-2 subunit |  |
Activity | = | 22.0 | % | Inhibition of recombinant AMPK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM | CHEMBL2331324 | |
| NAs.002742 | 7 | ribose-match | AMP-activated protein kinase, alpha-2 subunit |  |
Inhibition | = | -1.1 | % | GSK_PKIS: AMPKA2 (A2B1G1) mean inhibition at 0.1 uM [Nanosyn] | CHEMBL1961873 | |
| NAs.002742 | 7 | ribose-match | AMP-activated protein kinase, alpha-2 subunit | |
Inhibition | = | 1.47 | % | GSK_PKIS: AMPKA2 (A2B1G1) mean inhibition at 1 uM [Nanosyn] | CHEMBL1961873 | |
| NAs.002770 | 7 | ribose-match | AMP-activated protein kinase, alpha-2 subunit |  |
Kd | > | 10000.0 | nM | Binding constant for AMPK-alpha2 kinase domain | CHEMBL1150977 | |
| NAs.002770 | 7 | ribose-match | AMP-activated protein kinase, alpha-2 subunit | |
Thermal melting change | = | 0.4 | degrees C | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | CHEMBL1145498 | |
| NAs.002899 | 2 | all-match | AMP-activated protein kinase, alpha-2 subunit |  |
Thermal melting change | = | 1.0 | degrees C | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | CHEMBL1145498 | |
| NAs.003147 | 7 | all-match | AMP-activated protein kinase, alpha-2 subunit |  |
Activity | = | 29.0 | % | Inhibition of recombinant AMPK (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM | CHEMBL2331324 | |
| NAs.008387 | 7 | ribose-match | AMP-activated protein kinase, alpha-2 subunit |  |
Activity | = | 117.0 | % | Inhibition of recombinant full-length human AMPKalpha2 assessed as residual activity at 10 uM using AMARAASAAALARRR as substrate measured after 40 mins in presence of [gamma33P]ATP by scintillation counting method | CHEMBL4311992 | |