显示 1 到 50 条，共 79 条数据 每页数据量:
Compound ID
Cluster
Compound Type
Target Name Img Activity Assay Description Source
Type
Relation
Value
Unit
NAs.000283 7 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.000283 Residual Activity = 97.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.000283 7 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.000283 Residual Activity = 80.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.000283 7 ribose-match AMP-activated protein kinase, AMPK NAs.000283 Residual Activity = 86.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.000283 7 ribose-match AMP-activated protein kinase, AMPK NAs.000283 Residual Activity = 88.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.000318 7 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.000318 Residual Activity = 77.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.000318 7 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.000318 Residual Activity = 22.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.000318 7 ribose-match AMP-activated protein kinase, AMPK NAs.000318 Residual Activity = 64.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.000318 7 ribose-match AMP-activated protein kinase, AMPK NAs.000318 Residual Activity = 22.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.000539 7 ribose-match AMP-activated protein kinase, AMPK NAs.000539 Residual Activity = 48.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.000539 7 ribose-match AMP-activated protein kinase, AMPK NAs.000539 Residual Activity = 95.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.000539 7 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.000539 Residual Activity = 42.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.000539 7 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.000539 Residual Activity = 92.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.001019 7 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.001019 Residual Activity = 92.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.001019 7 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.001019 Residual Activity = 45.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.001019 7 ribose-match AMP-activated protein kinase, AMPK NAs.001019 Residual Activity = 87.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.001019 7 ribose-match AMP-activated protein kinase, AMPK NAs.001019 Residual Activity = 50.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.001167 7 base-match AMP-activated protein kinase, AMPK NAs.001167 Inhibition = -12.0 % Inhibition of AMPK (unknown origin) at 1 uM by [33P]-ATP filter-binding assay CHEMBL2424535
NAs.001310 7 ribose-match AMP-activated protein kinase, AMPK NAs.001310 Residual Activity = 90.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.001310 7 ribose-match AMP-activated protein kinase, AMPK NAs.001310 Residual Activity = 99.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.001310 7 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.001310 Residual Activity = 87.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.001310 7 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.001310 Residual Activity = 88.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.001855 7 all-match AMP-activated protein kinase, AMPK NAs.001855 Percent Effect = 5.252999999999999 % AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 CHEMBL3988442
NAs.002476 7 base-match AMP-activated protein kinase, AMPK NAs.002476 Inhibition = 78.0 % Inhibition of AMPK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control CHEMBL2417369
NAs.002871 2 all-match AMPK alpha2/beta1/gamma1 NAs.002871 EC50 = 1400.0 nM Allosteric activation of AMPK alpha2/beta1/gamma1 in human HepG2 cells by scintillation proximity assay CHEMBL4602612
NAs.002871 2 all-match AMPK alpha2/beta2/gamma1 NAs.002871 Activity None None None Activation of human recombinant AMPKalpha2beta2gamma1 expressed in Escherichia coli at 10 uM incubated for 1 hr using serine/threonine kinase substrate CHEMBL4130473
NAs.002871 2 all-match AMPK alpha2/beta1/gamma1 NAs.002871 Activity None None None Activation of human recombinant AMPKalpha2beta1gamma1 expressed in Escherichia coli at 10 uM incubated for 1 hr using serine/threonine kinase substrate CHEMBL4130473
NAs.002871 2 all-match AMPK alpha1/beta2/gamma1 NAs.002871 Activity None None None Activation of human recombinant AMPKalpha1beta2gamma1 expressed in Escherichia coli at 10 uM incubated for 1 hr using serine/threonine kinase substrate CHEMBL4130473
NAs.002871 2 all-match AMPK alpha1/beta1/gamma2 NAs.002871 Activity None None None Activation of human recombinant AMPKalpha1beta1gamma2 expressed in Escherichia coli at 10 uM incubated for 1 hr using serine/threonine kinase substrate CHEMBL4130473
NAs.002871 2 all-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.002871 Kd = 3700.0 nM Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assay CHEMBL3853317
NAs.002871 2 all-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.002871 Activity = 103.0 % Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphorylation preincubated for 15 mins followed by incubation with PP2a for 60 mins measured 60 mins post okadaic acid/Cy5-labelled SAMS and ATP addition by TR-FRET assay relative to AMP CHEMBL3853317
NAs.002871 2 all-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.002871 EC50 = 1519.0 nM Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphorylation preincubated for 15 mins followed by incubation with PP2a for 60 mins measured 60 mins post okadaic acid/Cy5-labelled SAMS and ATP addition by TR-FRET assay CHEMBL3853317
NAs.002871 2 all-match AMP-activated protein kinase, AMPK NAs.002871 EC50 = 5900.0 nM Activation of human AMPK after 15 mins CHEMBL1687696
NAs.002871 2 all-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.002871 Activity None None None Activation of human recombinant AMPKalpha1beta1gamma1 expressed in Escherichia coli at 10 uM incubated for 1 hr using serine/threonine kinase substrate CHEMBL4130473
NAs.002887 7 base-match AMP-activated protein kinase, AMPK NAs.002887 Inhibition = 66.0 % Inhibition of AMPK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control CHEMBL2417369
NAs.003626 2 all-match AMP-activated protein kinase, AMPK NAs.003626 EC50 None None None Activation of AMPK in human MDA-MB-435 cells measured after 2 hrs by anti-phospho-Acetyl-CoA Carboxylase (Ser79) antibody-based ELISA CHEMBL4627268
NAs.003642 2 all-match AMP-activated protein kinase, AMPK NAs.003642 Activity = 48.0 % Percent residual activity, relative to control, of AMPK at 1 uM concentration of inhibitor in presence of 50 uM ATP CHEMBL1137240
NAs.003723 2 ribose-match AMP-activated protein kinase, AMPK NAs.003723 Residual Activity = 102.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.003723 2 ribose-match AMP-activated protein kinase, AMPK NAs.003723 Residual Activity = 95.0 % Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.003723 2 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.003723 Residual Activity = 96.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.003723 2 ribose-match AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 NAs.003723 Residual Activity = 75.0 % Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP CHEMBL2218924
NAs.003853 7 all-match AMP-activated protein kinase, AMPK NAs.003853 Percent Effect = 0.9646 % AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 CHEMBL3988442
NAs.003884 7 all-match AMP-activated protein kinase, AMPK NAs.003884 Percent Effect = -12.88 % AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 CHEMBL3988442
NAs.004013 7 base-match AMP-activated protein kinase, AMPK NAs.004013 Inhibition = 70.0 % Inhibition of AMPK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control CHEMBL2417369
NAs.004101 7 all-match AMP-activated protein kinase, AMPK NAs.004101 Percent Effect = -1.11 % AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 CHEMBL3988442
NAs.004185 7 all-match AMP-activated protein kinase, AMPK NAs.004185 Percent Effect = 4.15 % AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 CHEMBL3988442
NAs.004958 7 all-match AMP-activated protein kinase, AMPK NAs.004958 Percent Effect = -24.62 % AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 CHEMBL3988442
NAs.004960 7 all-match AMP-activated protein kinase, AMPK NAs.004960 Percent Effect = -9.224 % AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 CHEMBL3988442
NAs.004976 7 all-match AMP-activated protein kinase, AMPK NAs.004976 Percent Effect = -2.46 % AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 CHEMBL3988442
NAs.004983 7 all-match AMP-activated protein kinase, AMPK NAs.004983 Percent Effect = 7.314 % AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 CHEMBL3988442
NAs.005029 7 all-match AMP-activated protein kinase, AMPK NAs.005029 Percent Effect = -4.702 % AMP-dependent Kinase enzyme assay. An in vitro enzyme assay that detects ADP turnover that is directly proportional to AMPK activity. This uses naive AMPK that is activated during the assay with MK-8722 CHEMBL3988442