| Compound ID |
Cluster
|
Compound Type
|
Target Name | Img | Activity | Assay Description | Source | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Type
|
Relation
|
Value
|
Unit
|
||||||||
| NAs.000030 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 2900.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.000068 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | > | 45000.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.000135 | 2 | ribose-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 3700.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.000143 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 18000.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.000195 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 2500.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.000278 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 2.9 | nM | Inhibition of DNMT1 (unknown origin) | CHEMBL4477246 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 700.0 | nM | Inhibition of human recombinant full-length DNMT1 expressed in Sf9 cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and [Me-3H]SAM as substrate incubated for 2 hrs by liquid scintillation counting analysis | CHEMBL5137006 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
IC50 | = | 71.0 | nM | Inhibition of recombinant human DNMT1 using poly(dl-dC) as substrate by hotspot assay | CHEMBL4680176 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
IC50 | = | 200.0 | nM | Inhibition of DNMT1 (unknown origin) | CHEMBL4477246 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
IC50 | = | 600.0 | nM | Inhibition of DNMT1 (unknown origin) using biotinylated substrate using [3H]-SAM after 1 hr by scintillation proximity assay | CHEMBL4422660 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
Inhibition | None | None | % | Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) at 200 uM expressed in Escherichia coli BL21 (DE3) incubated for 2 hrs using S-adenosylmethionine by ELISA | CHEMBL3351464 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
IC50 | = | 900.0 | nM | Inhibition of full length N-terminal His6-tagged human DNMT1 after 1 hr by fluorescence analysis | CHEMBL2046381 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
Inhibition | None | None | % | Inhibition of full length N-terminal His6-tagged human DNMT1 at 30 uM after 1 hr by fluorescence analysis | CHEMBL2046381 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
IC50 | = | 4000.0 | nM | Inhibition of human recombinant DNMT1 expressed in Sf9 cells assessed as incorporation of [3H]S-adenosyl methionine into hemimethylated oligonucleotide substrate after 3 hrs by scintillation counting | CHEMBL1914404 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
Activity | = | 0.5 | % | Inhibition of human recombinant DNMT1 expressed in Sf9 cells assessed as remaining activity at 2 mM after 3 hrs by scintillation counting in presence of [3H]S-adenosyl methionine | CHEMBL1914404 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
IC50 | = | 4000.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation counting | CHEMBL1157722 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
Inhibition | = | 26.0 | % | Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system at 100 uM by scintillation counting | CHEMBL1157722 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
IC50 | = | 800.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
IC50 | = | 2000.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.000315 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 | |
IC50 | = | 941.0 | nM | Inhibition of human Dnmt1 using oligonucleotide 2 as substrate after 5000 sec by micro plate reader based real-time break-light assay | CHEMBL2016468 | |
| NAs.000405 | 2 | ribose-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 6700.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.000444 | 2 | ribose-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 5400.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.000444 | 2 | ribose-match | DNA (cytosine-5)-methyltransferase 1 | |
IC50 | = | 5400.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.000518 | 2 | ribose-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 22000.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.000552 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 302000.0 | nM | Inhibition of human Dnmt1 using oligonucleotide 2 as substrate after 5000 sec by micro plate reader based real-time break-light assay | CHEMBL2016468 | |
| NAs.000649 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 6000.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.000740 | 2 | ribose-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 61000.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.000770 | 2 | ribose-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 2500.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.000820 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 4800.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.000831 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 1100.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.001038 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 21000.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.001049 | 2 | ribose-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 18000.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.001060 | 2 | ribose-match | DNA (cytosine-5)-methyltransferase 1 |  |
Ki | > | 50000.0 | nM | Inhibition of human DNMT1A using double-stranded hemi-DNA oligonucleotide as substrate measured after 40 mins by [3H]methyl incorporation assay | CHEMBL4270631 | |
| NAs.001424 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
Inhibition | None | None | % | Inhibition of DNMT1 (unknown origin) at 200 uM | CHEMBL3259565 | |
| NAs.001479 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 75000.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.001566 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 4000.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.001622 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | > | 100000.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.001671 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | > | 100000.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.001814 | 2 | ribose-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 27000.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.001816 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 820.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.002060 | 2 | ribose-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 154000.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.002121 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 31000.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.002151 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
Inhibition | = | 18.0 | % | Inhibition of human recombinant DNMT1 at 45 uM | CHEMBL1151876 | |
| NAs.002177 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
Inhibition | = | 1.0 | % | Inhibition of human recombinant DNMT1 at 45 uM | CHEMBL1151876 | |
| NAs.002471 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 216000.0 | nM | Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | CHEMBL1151871 | |
| NAs.002563 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 8000.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.002608 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | > | 100000.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.002616 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 36000.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.002702 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | > | 10000.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |
| NAs.002703 | 2 | all-match | DNA (cytosine-5)-methyltransferase 1 |  |
IC50 | = | 94000.0 | nM | Inhibition of human recombinant DNMT1 | CHEMBL1151876 | |