NA-DB

显示 1 到 50 条，共 66 条数据每页数据量:

Compound ID	Cluster 0 1 2 3 4 5 6 7 8 9	Compound Type ALL-match base match ribose match	Target Name	Img	Activity				Assay Description	Source
Compound ID	Cluster 0 1 2 3 4 5 6 7 8 9	Compound Type ALL-match base match ribose match	Target Name	Img	Type IC50 Ratio IC50 Inhibition	Relation = > None	Value	Unit nM None %	Assay Description	Source
NAs.000030	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	57200.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.000030	2	all-match	DNA (cytosine-5)-methyltransferase 3B		Ratio IC50	=	190.0	None	Ratio of SAH IC50 to compound IC50 for human recombinant DNMT3b2	CHEMBL1151871
NAs.000068	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	17000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.000135	2	ribose-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	260.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.000143	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	41000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.000195	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	6800.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.000195	2	all-match	DNA (cytosine-5)-methyltransferase 3B		Ratio IC50	=	22.0	None	Ratio of SAH IC50 to compound IC50 for human recombinant DNMT3b2	CHEMBL1151871
NAs.000315	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	300.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.000315	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	200.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.000315	2	all-match	DNA (cytosine-5)-methyltransferase 3B		Inhibition	=	28.0	%	Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system at 100 uM by scintillation counting	CHEMBL1157722
NAs.000315	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	250.0	nM	Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system by scintillation counting	CHEMBL1157722
NAs.000315	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	>	50000.0	nM	Inhibition of human full length DNMT3B expressed in Sf9 cells	CHEMBL3576805
NAs.000315	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	700.0	nM	Inhibition of human C-terminal domain DNMT3b catalytic domain (568 to 853 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and [Me-3H]SAM as substrate incubated for 45 mins in presence of DNMT3L by liquid scintillation counting analysis	CHEMBL5137006
NAs.000405	2	ribose-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	29000.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.000444	2	ribose-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	600.0	nM	Inhibition of human recombinant DNMT3b2 at 45 uM	CHEMBL1151876
NAs.000444	2	ribose-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	600.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.000518	2	ribose-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	3600.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.000649	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	1000.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.000740	2	ribose-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	1000.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.000770	2	ribose-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	920.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.000820	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	12000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.000831	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	300.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.001038	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	256000.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.001049	2	ribose-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	900.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.001304	2	all-match	DNA (cytosine-5)-methyltransferase 3B		Inhibition	=	0.0	%	Inhibition of human recombinant DNMT3b2 at 45 uM	CHEMBL1151876
NAs.001304	2	all-match	DNA (cytosine-5)-methyltransferase 3B		Inhibition	=	16.0	%	Inhibition of human recombinant DNMT3b2 at 45 uM	CHEMBL1151876
NAs.001479	2	all-match	DNA (cytosine-5)-methyltransferase 3B		Inhibition	None	None	%	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells at 45 uM	CHEMBL1151871
NAs.001566	2	all-match	DNA (cytosine-5)-methyltransferase 3B		Inhibition	=	50.0	%	Inhibition of human recombinant DNMT3b2 at 45 uM	CHEMBL1151876
NAs.001622	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	11000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.001671	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	54000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.001814	2	ribose-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	2000.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.001816	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	1900.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.002060	2	ribose-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	2000.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.002121	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	21000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.002151	2	all-match	DNA (cytosine-5)-methyltransferase 3B		Inhibition	=	51.0	%	Inhibition of human recombinant DNMT3b2 at 45 uM	CHEMBL1151876
NAs.002177	2	all-match	DNA (cytosine-5)-methyltransferase 3B		Inhibition	=	42.0	%	Inhibition of human recombinant DNMT3b2 at 45 uM	CHEMBL1151876
NAs.002306	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	>	50000.0	nM	Inhibition of human full length DNMT3B expressed in Sf9 cells	CHEMBL3576805
NAs.002471	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	500000.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.002563	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	1500.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.002608	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	39000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.002616	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	>	45000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.002702	2	all-match	DNA (cytosine-5)-methyltransferase 3B		Inhibition	=	32.0	%	Inhibition of human recombinant DNMT3b2 at 45 uM	CHEMBL1151876
NAs.002703	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	66000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.002817	2	ribose-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	600.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.002908	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	100000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.003079	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	>	100000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.003160	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	26000.0	nM	Inhibition of human recombinant DNMT3b2	CHEMBL1151876
NAs.003248	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	3000.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.003622	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	45000.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871
NAs.003711	2	all-match	DNA (cytosine-5)-methyltransferase 3B		IC50	=	300.0	nM	Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells	CHEMBL1151871